505
Participants
Start Date
March 7, 2022
Primary Completion Date
June 12, 2025
Study Completion Date
June 12, 2025
Non-adjuvanted HSV formulation 1
Two doses of the non-adjuvanted HSV formulation 1 vaccine administered intramuscularly in the deltoid region of the non-dominant arm, one each at Day 1 and Day 29, during Part I of the study.
Non-adjuvanted HSV formulation 2
Two doses of the non-adjuvanted HSV formulation 2 vaccine administered intramuscularly in the deltoid region of the non-dominant arm, one each at Day 1 and Day 29, during Part I of the study.
Non-adjuvanted HSV formulation 3
Two doses of the non-adjuvanted HSV formulation 3 vaccine administered intramuscularly in the deltoid region of the non-dominant arm, one each at Day 1 and Day 29, during Part I of the study.
HSV formulation 1 with adjuvant 1
Two doses of the HSV formulation 1 with adjuvant 1 vaccine administered intramuscularly in the deltoid region of the non-dominant arm, one each at Day 1 and Day 29, during Part I of the study.
HSV formulation 2 with adjuvant 1
Two doses of the HSV formulation 2 with adjuvant 1 vaccine administered intramuscularly in the deltoid region of the non-dominant arm, one each at Day 1 and Day 29, during Part I of the study.
HSV formulation 3 with adjuvant 1
Two doses of the HSV formulation 3 with adjuvant 1 vaccine administered intramuscularly in the deltoid region of the non-dominant arm, one each at Day 1 and Day 29, during Part I of the study.
HSV formulation 1 with adjuvant 2
Two doses of the HSV formulation 1 with adjuvant 2 vaccine administered intramuscularly in the deltoid region of the non-dominant arm, one each at Day 1 and Day 29, during Part I of the study.
HSV formulation 2 with adjuvant 2
Two doses of the HSV formulation 2 with adjuvant 2 vaccine administered intramuscularly in the deltoid region of the non-dominant arm, one each at Day 1 and Day 29, during Part I of the study.
HSV formulation 3 with adjuvant 2
Two doses of the HSV formulation 3 with adjuvant 2 vaccine administered intramuscularly in the deltoid region of the non-dominant arm, one each at Day 1 and Day 29, during Part I of the study.
Placebo
Two doses of Placebo administered intramuscularly in the deltoid region of the non-dominant arm, one each at Day 1 and Day 29, during Part I and Part II of the study.
HSVTI_F1
Two doses of the formulation of the HSVTI\_F1 selected from Part I of the study administered intramuscularly in the deltoid region of the non-dominant arm, one each at Day 1 and Day 29, during Part II of the study.
HSVTI_F2
Two doses of the formulation of the HSVTI\_F2 selected from Part I of the study administered intramuscularly in the deltoid region of the non-dominant arm, one each at Day 1 and Day 29, during Part II of the study.
GSK Investigational Site, Brussels
GSK Investigational Site, Antwerp
GSK Investigational Site, Darlinghurst
GSK Investigational Site, Sydney
GSK Investigational Site, Edegem
GSK Investigational Site, Ghent
GSK Investigational Site, Berlin
GSK Investigational Site, Berlin
GSK Investigational Site, Rochester
GSK Investigational Site, Hamburg
GSK Investigational Site, Richmond
GSK Investigational Site, Madrid
GSK Investigational Site, Madrid
GSK Investigational Site, Madrid
GSK Investigational Site, Marbella
GSK Investigational Site, Bochum
GSK Investigational Site, Tartu
GSK Investigational Site, Cologne
GSK Investigational Site, Frankfurt
GSK Investigational Site, Kansas City
GSK Investigational Site, Wichita
GSK Investigational Site, Phoenix
GSK Investigational Site, Seattle
GSK Investigational Site, Montreal
GSK Investigational Site, Barcelona
GSK Investigational Site, Barcelona
GSK Investigational Site, Brighton
GSK Investigational Site, Liverpool
GSK Investigational Site, London
GSK Investigational Site, Southampton
Lead Sponsor
GlaxoSmithKline
INDUSTRY