Pembrolizumab and Lenvatinib in Clear Cell Ovarian Cancer

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

September 23, 2022

Primary Completion Date

November 15, 2025

Study Completion Date

November 15, 2027

Conditions
Ovarian Clear Cell CarcinomaGynecologic Cancer
Interventions
DRUG

Lenvatinib

Lenvatinib is an oral capsule medication that will be taken by mouth once daily, every day of each 21-day treatment cycle. Treatment will be administered on an outpatient basis.

DRUG

Pembrolizumab

"Pembrolizumab will be administered intravenously (IV) on Day 1 of every 21-day treatment cycle. Treatment will be administered on an outpatient basis.~Pembrolizumab will be given up to 35 cycles (approximately 24 months). Participants who stop pembrolizumab treatment with SD or better may be eligible for up to an additional 17 cycles (approximately 12 months) of pembrolizumab treatment (Pembrolizumab Re-Treatment) if they progress after stopping pembrolizumab and while receiving lenvatinib."

Trial Locations (3)

55905

Mayo Clinic Comprehensive Cancer Center, Rochester

60637

University of Chicago Medicine, Chicago

02115

Dana Farber Cancer Institute, Boston

All Listed Sponsors
collaborator

Merck Sharp & Dohme LLC

INDUSTRY

lead

Joyce Liu, MD

OTHER

NCT05296512 - Pembrolizumab and Lenvatinib in Clear Cell Ovarian Cancer | Biotech Hunter | Biotech Hunter