A Study of Bexarotene Combined With Radiotherapy in People With Mycosis Fungoides

PHASE1RecruitingINTERVENTIONAL
Enrollment

20

Participants

Timeline

Start Date

March 16, 2022

Primary Completion Date

March 31, 2026

Study Completion Date

March 31, 2026

Conditions
Cutaneous T-cell Lymphoma
Interventions
DRUG

Bexarotene

Orally every day starting at the dose of 150 mg/day flat dose. At Day 15, if the treatment is tolerated, patients will escalate the dose of bexarotene to 300 mg/day, and that dose will remain constant during the rest of the study.

RADIATION

Total Skin Electron Beam (TSEB)

At Day 21, if the bexarotene has shown to be tolerated, patients will receive the first dose of TSEB (2 Gy x 2).

Trial Locations (1)

10065

RECRUITING

Memorial Sloan Kettering Cancer Center (All Protocol Activities), New York

All Listed Sponsors
lead

Memorial Sloan Kettering Cancer Center

OTHER