Open-label of Loncastuximab Tesirine (ADCT-402) in Relapsed/Refractory Marginal Zone Lymphoma

PHASE2RecruitingINTERVENTIONAL
Enrollment

50

Participants

Timeline

Start Date

June 21, 2022

Primary Completion Date

June 30, 2028

Study Completion Date

June 30, 2029

Conditions
Marginal Zone Lymphoma
Interventions
DRUG

Loncastuximab tesirine 150 µg/Kg

Participants will be treated with loncastuximab tesirine at a dose of 150 µg/Kg given as an intravenous infusion (given as per treatment guidelines for 30 minutes or longer) on Day 1 (+/- 3 days) of each 21 day cycle for Cycle 1 - 2.

DRUG

Loncastuximab tesirine 75µg/Kg

Participants will be treated with loncastuximab tesirine at a dose of 75 µg/Kg given as an intravenous infusion (given as per treatment guidelines for 30 minutes or longer) on Day 1 (+/- 3 days) of each 21 day cycle for Cycle 3 - 6.

Trial Locations (4)

30322

RECRUITING

Emory University, Atlanta

33136

RECRUITING

University of Miami, Miami

37232

RECRUITING

Vanderbilt University, Nashville

91010

RECRUITING

City of Hope National Medical Center, Duarte

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

ADC Therapeutics S.A.

INDUSTRY

lead

University of Miami

OTHER