Compare Continuation of Original Targeted Therapy With Trastuzumab Combined With Pyrotinib and Capecitabine as Postoperative Adjuvant Therapy in Non-pCR Patients With HER2 Positive Early Breast Cancer

PHASE2RecruitingINTERVENTIONAL
Enrollment

206

Participants

Timeline

Start Date

July 2, 2021

Primary Completion Date

October 1, 2026

Study Completion Date

December 31, 2027

Conditions
Breast CancerAdjuvant Therapy
Interventions
DRUG

Pyrotinib+Trastuzumab+Capecitabine

Patients in the experimental arm will receive trastuzumab + pyrotinib + capecitabine

DRUG

Trastuzumab+Pertuzumab/Trastuzumab

Trastuzumab: Initial loading dose of 8 mg/kg followed by 6 mg/kg every 3 weeks. One year of trastuzumab treatment (including: neoadjuvant phase and adjuvant phase) Pertuzumab: 840 mg loading dose followed by 420 mg fixed dose

Trial Locations (1)

350001

RECRUITING

Fujian Medical University Union Hospital, Fuzhou

All Listed Sponsors
lead

Fujian Medical University Union Hospital

OTHER