Vascular Endothelial Dysfunction in Sleep Apnea

PHASE1RecruitingINTERVENTIONAL
Enrollment

110

Participants

Timeline

Start Date

October 3, 2022

Primary Completion Date

February 28, 2026

Study Completion Date

February 28, 2026

Conditions
Obstructive Sleep Apnea of Adult
Interventions
DRUG

Atorvastatin 10mg

Atorvastatin 10 mg daily for 28 days will be randomly allocated to OSA patients regardless of adherence with CPAP. Atorvastatin and placebo will be encapsulated to appear identical and dispensed by the research pharmacy.

DRUG

Placebo

Placebo daily for 28 days will be randomly allocated to OSA patients regardless of adherence with CPAP. Atorvastatin and placebo will be encapsulated to appear identical and dispensed by the research pharmacy.

OTHER

Continuous Positive Airway Pressure Therapy

CPAP is a standard of care for OSA and will be prescribed by care providers not associated with this study based on clinical indications. The investigators will have no role in prescribing CPAP.

Trial Locations (1)

10032

RECRUITING

Columbia University Irving Medical Center, New York

All Listed Sponsors
collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

lead

Columbia University

OTHER