1,270
Participants
Start Date
March 30, 2022
Primary Completion Date
November 22, 2023
Study Completion Date
November 27, 2023
AS03
AS03 oil-in-water emulsion adjuvant.
BNT162b2
A nucleoside-modified messenger RNA (modRNA) encoding the viral spike glycoprotein (S) of SARS-CoV-2.
BNT162b2 (B.1.1.529)
A preservative-free, sterile dispersion of RNA formulated in LNP in aqueous cryoprotectant buffer contains mRNA that encodes for the prefusion stabilized S protein of the B.1.1.529 (Omicron) variant SARS-CoV-2 strain.
BNT162b2 (B.1.351)
A preservative-free, sterile dispersion of RNA formulated in LNP in aqueous cryoprotectant buffer contains mRNA that encodes for the prefusion stabilized S protein of the B.1.351 (Beta) variant SARS-CoV-2 strain.
BNT162b2 bivalent (wildtype and Omicron BA.1)
A preservative-free, sterile dispersion of RNA formulated in LNP in aqueous cryoprotectant buffer. Contains mRNA that encodes for the prefusion stabilized S protein of the Omicron BA.1 variant SARS-CoV-2 strain and the ancestral strain of SARS-CoV-2.
BNT162b2 bivalent (wildtype and Omicron BA.4/BA.5)
A preservative-free, sterile dispersion of RNA formulated in LNP in aqueous cryoprotectant buffer. Contains mRNA that encodes for the prefusion stabilized S protein of the Omicron BA.4/BA.5 variant SARS-CoV-2 strain and the ancestral strain of SARS-CoV-2.
CoV2 preS dTM [B.1.351]
Is a liquid formulation made of recombinant protein placed in a formulation buffer that contains the spike protein sequence of the B.1.351 (Beta) variant SARS-CoV-2 strain.
CoV2 preS dTM/D614
Is a liquid formulation made of recombinant protein placed in a formulation buffer. The antigen solution contains the spike protein sequence of the ancestral strain of SARS-CoV-2.
CoV2 preS dTM/D614+B.1.351
Is a liquid formulation made of recombinant protein placed in a formulation buffer contains the spike protein sequences of the ancestral and B.1.351 (Beta) variant SARS-CoV-2 strains
mRNA-1273
Lipid nanoparticle (LNP) dispersion containing an mRNA that encodes for the prefusion stabilized spike (S) protein of the 2019 novel coronavirus (2019-nCoV).
mRNA-1273.351
Lipid nanoparticle (LNP) dispersion containing an mRNA that encodes for the pre fusion stabilized spike (S) protein of the B.1.351 variant SARS-CoV-2 strain.
mRNA-1273.529
Lipid nanoparticle (LNP) dispersion containing an mRNA that encodes for the prefusion stabilized S protein of the B.1.1.529 (Omicron) variant SARS-CoV-2 strain.
mRNA-1273.617.2
Lipid nanoparticle (LNP) dispersion containing an mRNA that encodes for the prefusion stabilized S protein of the B.1.617.2 (Delta) variant SARS-CoV-2 strain.
Sodium Chloride, 0.9%
0.9% Sodium Chloride Injection
NYU Langone Vaccine Center Research Clinic, Manhattan, New York
NYU Grossman School, NYU Langone Vaccine Center, Long Island, Mineola
Howard University - Department of Medicine - Division of Infectious Disease, Washington D.C.
Duke Vaccine and Trials Unit, Durham
Morehouse School of Medicine - Clinical Research Center, Atlanta
University of Alabama at Birmingham School of Medicine - Alabama Vaccine Research Clinic, Birmingham
University of Iowa Hospitals & Clinics - Department of Internal Medicine, Iowa City
University of Illinois at Chicago College of Medicine - Division of Infectious Diseases, Chicago
Washington University School of Medicine in St. Louis - Infectious Disease Clinical Research Unit, St Louis
Tulane University Clinical Translational Unit, New Orleans
University of Texas Medical Branch, League City
Zuckerberg San Francisco General Hospital, UCSF Positive Health Program, San Francisco
Kaiser Permanente Washington Health Research Institute, Seattle
The University of Washington - Virology Research Clinic, Seattle
University of California, San Diego (UCSD) - Antiviral Research Center (AVRC), San Diego
George Washington University Medical Faculty Associates, Washington D.C.
Emory University School of Medicine, Atlanta
The Hope Clinic of Emory University, Decatur
Brigham and Women's Hospital, Boston
Saint Louis University Center for Vaccine Development, St Louis
University of Rochester Medical Center - Vaccine Research Unit, Rochester
Baylor College of Medicine, Houston
National Institute of Allergy and Infectious Diseases (NIAID)
NIH