Tiragolumab and Atezolizumab for the Treatment of Relapsed or Refractory SMARCB1 or SMARCA4 Deficient Tumors

PHASE1/PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

86

Participants

Timeline

Start Date

November 17, 2022

Primary Completion Date

March 31, 2030

Study Completion Date

March 31, 2030

Conditions
Atypical Teratoid/Rhabdoid TumorEpithelioid SarcomaKidney Medullary CarcinomaMalignant Solid NeoplasmPoorly Differentiated ChordomaRecurrent Atypical Teratoid/Rhabdoid TumorRecurrent ChordomaRecurrent Epithelioid SarcomaRecurrent Kidney Medullary CarcinomaRecurrent Malignant Solid NeoplasmRecurrent Rhabdoid TumorRefractory Atypical Teratoid/Rhabdoid TumorRefractory ChordomaRefractory Epithelioid SarcomaRefractory Kidney Medullary CarcinomaRefractory Malignant Solid NeoplasmRefractory Rhabdoid TumorRhabdoid Tumor
Interventions
BIOLOGICAL

Atezolizumab

Given IV

PROCEDURE

Biospecimen Collection

Undergo blood sample collection

PROCEDURE

Computed Tomography

Undergo CT and/or PET-CT

PROCEDURE

Echocardiography Test

Undergo ECHO

OTHER

Fludeoxyglucose F-18

Given FDG

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

PROCEDURE

Positron Emission Tomography

Undergo PET-CT and/or FDG-PET

BIOLOGICAL

Tiragolumab

Given IV

PROCEDURE

X-Ray Imaging

Undergo x-rays

Trial Locations (40)

2031

Sydney Children's Hospital, Randwick

3052

Royal Children's Hospital, Parkville

4101

Queensland Children's Hospital, South Brisbane

10032

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York

10065

Memorial Sloan Kettering Cancer Center, New York

10595

New York Medical College, Valhalla

15224

Children's Hospital of Pittsburgh of UPMC, Pittsburgh

19104

Children's Hospital of Philadelphia, Philadelphia

20010

Children's National Medical Center, Washington D.C.

20892

National Institutes of Health Clinical Center, Bethesda

21287

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore

27710

Duke University Medical Center, Durham

30329

Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta

35233

Children's Hospital of Alabama, Birmingham

37232

Vanderbilt University/Ingram Cancer Center, Nashville

38105

Saint Jude Children's Research Hospital, Memphis

43205

Nationwide Children's Hospital, Columbus

45229

Cincinnati Children's Hospital Medical Center, Cincinnati

46202

Riley Hospital for Children, Indianapolis

48109

C S Mott Children's Hospital, Ann Arbor

53226

Children's Hospital of Wisconsin, Milwaukee

55455

University of Minnesota/Masonic Cancer Center, Minneapolis

60611

Lurie Children's Hospital-Chicago, Chicago

60637

University of Chicago Comprehensive Cancer Center, Chicago

63110

Washington University School of Medicine, St Louis

64108

Children's Mercy Hospitals and Clinics, Kansas City

75390

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

76104

Cook Children's Medical Center, Fort Worth

77030

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston

80045

Children's Hospital Colorado, Aurora

84113

Primary Children's Hospital, Salt Lake City

90027

Children's Hospital Los Angeles, Los Angeles

92868

Children's Hospital of Orange County, Orange

94158

UCSF Medical Center-Mission Bay, San Francisco

94304

Lucile Packard Children's Hospital Stanford University, Palo Alto

97239

Oregon Health and Science University, Portland

98105

Seattle Children's Hospital, Seattle

02215

Dana-Farber Cancer Institute, Boston

M5G 1X8

Hospital for Sick Children, Toronto

H3T 1C5

Centre Hospitalier Universitaire Sainte-Justine, Montreal

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH