Ocrelizumab Discontinuation in Relapsing Multiple Sclerosis

PHASE4RecruitingINTERVENTIONAL
Enrollment

123

Participants

Timeline

Start Date

January 12, 2023

Primary Completion Date

May 1, 2030

Study Completion Date

November 1, 2030

Conditions
Multiple Sclerosis
Interventions
DRUG

Ocrelizumab

Two 300 mg intravenous (IV) OCR infusions separated by 14 days (i.e., Days 0 and 14) for a total of 600 mg, followed by 600 mg OCR infusions every 6 months from Month 6 through Month 48.

DRUG

Placebo for Ocrelizumab

Placebo infusions every 6 months from Month 30 through Month 48.

Trial Locations (11)

10007

RECRUITING

Icahn School of Medicine at Mount Sinai, New York

14627

RECRUITING

University of Rochester Medical Center, Rochester

19104

RECRUITING

University of Pennsylvania, Perelman School of Medicine, Philadelphia

20007

RECRUITING

MedStar Georgetown University Hospital, Washington D.C.

23298

RECRUITING

Virginia Commonwealth University School of Medicine, Richmond

73104

RECRUITING

Oklahoma Medical Research Foundation, Oklahoma City

75390

RECRUITING

University of Texas Southwestern Medical Center, Dallas

77030

RECRUITING

The University of Texas Health Science Center at Houston, McGovern Medical School, Houston

06510

RECRUITING

Yale School of Medicine, New Haven

02114

RECRUITING

Massachusetts General Hospital, Boston

01655

RECRUITING

University of Massachusetts Memorial Medical Center, Worcester

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Autoimmunity Centers of Excellence (ACE)

UNKNOWN

collaborator

Rho Federal Systems Division, Inc.

INDUSTRY

collaborator

Genentech, Inc.

INDUSTRY

lead

National Institute of Allergy and Infectious Diseases (NIAID)

NIH

NCT05285891 - Ocrelizumab Discontinuation in Relapsing Multiple Sclerosis | Biotech Hunter | Biotech Hunter