Clinic-based Versus Hotspot-focused Active TB Case Finding

NARecruitingINTERVENTIONAL
Enrollment

150,000

Participants

Timeline

Start Date

June 1, 2022

Primary Completion Date

January 31, 2027

Study Completion Date

January 31, 2027

Conditions
Tuberculosis, PulmonaryMycobacterium Tuberculosis Infection
Interventions
OTHER

Active TB case finding with linkage to preventive therapy (ACF/TPT)

ACF/TPT in both intervention arms will consist of TB screening by mobile chest X-ray (with artificial intelligence-based reading, followed by confirmatory sputum testing with Xpert MTB/RIF Ultra for participants with abnormal x-rays), and linkage to preventive therapy for those who are TB-negative and eligible for TPT (limited in April 2024 to those with close TB contact or known HIV infection).

Trial Locations (1)

Unknown

RECRUITING

Walimu, Kampala

All Listed Sponsors
collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

collaborator

Walimu

OTHER

lead

Johns Hopkins University

OTHER