Sickle Cell Disease (SCD) Bone Pain Study

NAActive, not recruitingINTERVENTIONAL
Enrollment

53

Participants

Timeline

Start Date

November 3, 2022

Primary Completion Date

April 30, 2024

Study Completion Date

July 31, 2026

Conditions
Sickle Cell DiseaseSickle Cell AnemiaLow Bone DensityOsteoporosisOsteopeniaVertebral FractureVertebral CompressionOsteonecrosisIschemic NecrosisAvascular Necrosis
Interventions
OTHER

Dual-energy X-ray absorptiometry

Measure bone mineral density at the lumbar spine, left total hip, left forearm, and whole body

OTHER

Vertebral fracture analysis

Obtain thoracolumbar morphometry in DXA scan, then determine presence and severity of vertebral compression fractures by VFA

OTHER

Adult Sickle Cell Quality of Life Measurement System pain impact questionnaire

Calculate patient-reported total pain scores to determine the pain phenotype of each study participant

Trial Locations (1)

95817

UC Davis Comprehensive Cancer Center, Sacramento

All Listed Sponsors
collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

collaborator

Doris Duke Charitable Foundation

OTHER

lead

University of California, Davis

OTHER