103
Participants
Start Date
April 20, 2022
Primary Completion Date
December 31, 2026
Study Completion Date
December 31, 2026
Transdermal Estradiol
Participants will be randomized to receive transdermal estradiol (100μg/day) patch for 3 weeks.
Micronized Progesterone
Participants will receive an additional week of micronized progesterone (200 mg/day) at the end of the study to precipitate menstruation.
Matching Placebo Patch
Participants will be randomized to receive a transdermal estradiol-matching placebo patch for 3 weeks
Raclopride C11
All Participants will receive two PET-MR scans using \[11C\]raclopride IV as the tracer. The first scan will occur at baseline and the second at post treatment after 3 weeks.
RECRUITING
University of North Carolina at Chapel Hill, Chapel Hill
National Institute of Mental Health (NIMH)
NIH
University of North Carolina, Chapel Hill
OTHER