An Efficacy and Safety Study of a Combination of JNJ-73763989, Nucleos(t)Ide Analogs (NA), and a Programmed Cell Death Protein Receptor-1 (PD-1) Inhibitor in Chronic Hepatitis B Participants

PHASE2CompletedINTERVENTIONAL
Enrollment

37

Participants

Timeline

Start Date

June 30, 2022

Primary Completion Date

December 12, 2023

Study Completion Date

May 31, 2024

Conditions
Hepatitis B, Chronic
Interventions
DRUG

JNJ-73763989

JNJ-73763989 will be administered subcutaneously.

DRUG

PD-1 inhibitor

PD-1 inhibitor will be administered as IV infusion.

DRUG

Tenofovir Disoproxil

Tenofovir disoproxil film-coated tablets will be administered orally.

DRUG

Tenofovir Alafenamide

TAF film-coated tablets will be administered orally.

DRUG

Entecavir

ETV film-coated tablets will be administered orally.

Trial Locations (26)

824

E-DA Hospital, Kaohsiung City

8035

Hosp Univ Vall D Hebron, Barcelona

13008

Hopital Saint Joseph, Marseille

20122

Fondazione IRCCS Ca Granda Ospedale Policlinico Di Milano, Milan

28222

Hosp. Univ. Pta. de Hierro Majadahonda, Madrid

33305

Linkou Chang Gung Memorial Hospital, Taoyuan District

34098

Istanbul University Cerrahpasa Medical Faculty, Istanbul

35000

Chu Rennes Hopital Pontchaillou, Rennes

35040

Ege University Medical Faculty, Izmir

36071

Hosp. Montecelo, Pontevedra

40447

China Medical University Hospital, Taichung

41001

Kocaeli University Medical Faculty, Kocaeli

46014

Hosp. Gral. Univ. Valencia, Valencia

54500

CHRU Nancy Brabois, Vandœuvre-lès-Nancy

56124

Azienda Ospedaliero Universitaria Pisana, Pisa

61080

Karadeniz Teknik University Medical Faculty, Trabzon

80756

Kaohsiung Medical University Chung Ho Memorial Hospital, Kaohsiung City

92110

Hopital Beaujon, Clichy

M5G 2C4

Toronto General Hospital, Toronto

500 05

Fakultni nemocnice Hradec Kralove, Hradec Králové

140 21

IKEM, Prague

00161

Universita degli Studi di Roma 'La Sapienza' - Umberto I Policlinico di Roma, Rome

06230

Hacettepe University Medical Faculty, Ankara

G31 2ER

Glasgow Royal Infirmary, Glasgow

SE5 9RS

Kings College Hospital, London

W2 1NY

Imperial College London and Imperial College Healthcare NHS Trust, London

All Listed Sponsors
lead

Janssen Research & Development, LLC

INDUSTRY