Characterization of Bovine Adrenal Medulla as a New Surrogate Model of Non-histaminergic Itch

NACompletedINTERVENTIONAL
Enrollment

22

Participants

Timeline

Start Date

February 11, 2022

Primary Completion Date

May 30, 2022

Study Completion Date

October 30, 2022

Conditions
Itch
Interventions
DRUG

A-967079 and BAM8-22 application

A-967079 solution (in PBS 0.5 mg/ml, subcutaneous injection of 0.1ml) and BAM8-22 with inactivate cowhage spicules 20 µl of BAM8-22 will be applied to a previously determined area on the volar forearm using inactivate cowhage spicules

DRUG

A-967079 and BAM8-22 application after 5 minutes.

A-967079 solution (in PBS 0.5 mg/ml, subcutaneous injection of 0.1ml). BAM8-22 with inactivate cowhage spicules 20 µl of BAM8-22 will be applied 5 minutes after to a previously determined area on the volar forearm using inactivate cowhage spicules

DRUG

A-967079 application.

A-967079 solution (in PBS 0.5 mg/ml, subcutaneous injection of 0.1ml) will be applied to a previously determined area on the volar forearm

DRUG

Vehicle and BAM8-22 application.

Vehicle (in PBS, subcutaneous injection of 0.1ml) and BAM8-22 with inactivate cowhage spicules 20 µl of BAM8-22 will be applied to a previously determined area on the volar forearm using inactivate cowhage spicules

Trial Locations (1)

9000

Giulia Erica Aliotta, Aalborg

All Listed Sponsors
lead

Aalborg University

OTHER