Sintilimab Plus NCT or NCRT Versus NCRT for ESCC

PHASE3Not yet recruitingINTERVENTIONAL
Enrollment

420

Participants

Timeline

Start Date

November 1, 2022

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2026

Conditions
Esophageal Squamous Cell Carcinoma
Interventions
DRUG

Sintilimab

Sintilimab: D1 administration) for 2 cycles. Every 3 weeks was a dosing cycle (Q3W)

RADIATION

radiotherapy

Radiotherapy: According to IMRT treatment plan, the total dose was 41.4Gy, divided into 23 times, 5 days a week.

DRUG

Chemotherapy

Neoadjuvant chemotherapy with TP regimen: albumin-paclitaxel + carboplatin, D1 administration) for 2 cycles. Every 3 weeks was a dosing cycle (Q3W).

Trial Locations (1)

610041

Sichuan Cancer Hospital and Research Institute, Chengdu

Sponsors
All Listed Sponsors
collaborator

Peking University Cancer Hospital & Institute

OTHER

collaborator

Tianjin Medical University Cancer Institute and Hospital

OTHER

collaborator

Hebei Medical University Fourth Hospital

OTHER

collaborator

Anhui Provincial Hospital

OTHER_GOV

collaborator

The First Affiliated Hospital with Nanjing Medical University

OTHER

collaborator

Anyang Tumor Hospital

OTHER

collaborator

Shantou Central Hospital

OTHER

collaborator

Innovent Biologics (Suzhou) Co. Ltd.

INDUSTRY

collaborator

GeneCast Biotechnology Co., Ltd.

INDUSTRY

lead

Sichuan Cancer Hospital and Research Institute

OTHER

NCT05244798 - Sintilimab Plus NCT or NCRT Versus NCRT for ESCC | Biotech Hunter | Biotech Hunter