(Concerto) Study of BLU-451 in Advanced Cancers With EGFR Exon 20 Insertion Mutations

PHASE1TerminatedINTERVENTIONAL
Enrollment

103

Participants

Timeline

Start Date

March 4, 2022

Primary Completion Date

July 31, 2024

Study Completion Date

July 31, 2024

Conditions
Lung Neoplasm MalignantCarcinoma, Non-Small-Cell LungRespiratory Tract NeoplasmsNeoplasmsNeoplasms by SiteLung DiseasesRespiratory Tract DiseaseCarcinoma, BronchogenicBronchial NeoplasmsAdenocarcinomaCarcinomaNeoplasms by Histologic TypeEGFR Exon 20 MutationEGFR Exon 20 Insertion MutationEGFR Activating MutationAntineoplastic AgentsMetastatic Lung CancerBrain MetastasesEGFR-mutated NSCLCEGFR Atypical Mutations, Including G719X and L861Q
Interventions
DRUG

BLU-451

BLU-451 will be administered orally by tablet QD or BID on a 21-day treatment cycle

DRUG

Carboplatin

Carboplatin will be administered intravenously (IV) on Day 1 of each cycle (every 3 weeks) for 4 to 6 cycles

DRUG

Pemetrexed

Pemetrexed will be administered prior to carboplatin as an IV infusion on Day 1 of each cycle (every 3 weeks)

Trial Locations (23)

100

National Taiwan University Hospital, Taipei

112

Taipei Veterans General Hospital, Taipei

333

Linkou Chang Gung Memorial Hospital (CGMHLK), Taoyuan District

1650

Taichung Veterans General Hospital, Taichung

10016

Laura & Isaac Perlmutter Cancer Center at NYU Langone Health, New York

10065

Memorial Sloan Kettering Cancer Center, New York

19104

Hospital of the University of Pennsylvania, Philadelphia

20007

Georgetown University Medical Center, Washington D.C.

22031

New Experimental Therapeutics of Virginia (NEXT Oncology), Fairfax

60611

Northwestern Memorial Hospital, Chicago

80045

University of Colorado Hospital - Anschutz Cancer Pavilion (ACP), Aurora

90048

Cedars-Sinai Medical Center, Samuel Oschin Comprehensive Cancer Institute, Los Angeles

91010

City of Hope (City of Hope National Medical Center, City of Hope Medical Center), Duarte

98109

Fred Hutchinson Cancer Center, Seattle

02114

Massachusetts General Hospital, Boston

02215

Dana-Farber Cancer Institute, Boston

77030-4009

The University of Texas M.D. Anderson Cancer Center, Houston

M5G 2M9

Princess Margaret Cancer Centre, Toronto

277-8577

National Cancer Center Hospital East, Kashiwa

241-8515

Kanagawa Cancer Center, Yokohama

104-0045

National Cancer Center Hospital, Chuo-ku

03722

Severance Hospital, Yonsei University Health System, Seoul

05505

Asan Medical Center, Seoul

All Listed Sponsors
lead

Blueprint Medicines Corporation

INDUSTRY