CD4^LVFOXP3 in Participants With IPEX

PHASE1RecruitingINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

March 22, 2022

Primary Completion Date

February 28, 2027

Study Completion Date

February 28, 2037

Conditions
IPEX
Interventions
BIOLOGICAL

CD4^LVFOXP3

"Infusion of autologous CD4+ T cells that have undergone lentiviral-mediated gene transfer of:~i) healthy human FOXP3 gene leading to persistent high FOXP3 expression and acquisition of Treg-like cell function; and ii) human CD271 surface marker gene that allows tracking and quantification of the CD4\^LVFOXP3 in the blood."

Trial Locations (1)

94305

RECRUITING

Lucile Packard Children's Hospital, Palo Alto

All Listed Sponsors
collaborator

California Institute for Regenerative Medicine (CIRM)

OTHER

lead

Bacchetta, Rosa, MD

OTHER