Study of Pembrolizumab (MK-3475) Versus Chemotherapy in Chinese Participants With Stage IV Colorectal Cancer (MK-3475-C66)

PHASE3RecruitingINTERVENTIONAL
Enrollment

100

Participants

Timeline

Start Date

April 2, 2022

Primary Completion Date

September 19, 2028

Study Completion Date

September 19, 2028

Conditions
Colorectal Neoplasms
Interventions
BIOLOGICAL

Pembrolizumab

Intravenous (IV) infusion

DRUG

Oxaliplatin

85 mg/m\^2 given as an intravenous infusion (IV) on Day 1 in each 14-day cycle (Q2W) as part of the mFOLFOX6 regimen

DRUG

Leucovorin

400 mg/m\^2 given as an IV on Day 1 Q2W as part of the mFOLFOX6 and FOLFIRI regimens

DRUG

5-fluorouracil

400 mg/m\^2 given as an IV bolus on Day 1 and then 1200 mg/m\^2/day IV over 2 days for a total dose of 2400 mg/m\^2 Q2W as part of the mFOLFOX6 and FOLFIRI regimens

DRUG

Irinotecan

180 mg/m\^2 IV on Day 1 Q2W as part of the FOLFIRI regimen

BIOLOGICAL

Bevacizumab

IV infusion

BIOLOGICAL

Cetuximab

IV infusion

Trial Locations (32)

100142

RECRUITING

Beijing Cancer hospital-Digestive Oncology ( Site 0001), Beijing

100730

COMPLETED

Beijing Peking Union Medical College Hospital-Medical Oncology ( Site 0011), Beijing

110001

COMPLETED

The first affiliated hospital of China medical university ( Site 0043), Shemyang

150081

RECRUITING

Harbin Medical University Cancer Hospital ( Site 0007), Harbin

200032

RECRUITING

Fudan University Shanghai Cancer Center-Oncology ( Site 0046), Shanghai

200120

RECRUITING

Shanghai East Hospital ( Site 0022), Shanghai

200433

COMPLETED

Shanghai Changhai Hospital ( Site 0024), Shanghai

210008

RECRUITING

Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School-Oncology ( Site 0002), Nanjing

214400

RECRUITING

The Affiliated Jiangyin Hospital of Southeast University Medical College ( Site 0037), Jiangyin

250013

COMPLETED

Jinan Central Hospital-oncology department ( Site 0021), Jinan

250117

RECRUITING

Shandong Cancer Hospital ( Site 0041), Jinan

310022

RECRUITING

Zhejiang Cancer Hospital-oncology-abdominal neoplasms ( Site 0028), Hangzhou

350014

RECRUITING

Fujian Provincial Cancer Hospital ( Site 0009), Fuzhou

400016

RECRUITING

The First Affiliated Hospital of Chongqing Medical University ( Site 0051), Chongqing

400030

RECRUITING

Chongqing University Cancer Hospital-Medical Oncology ( Site 0012), Chongqing

410013

RECRUITING

The Third Xiangya Hospital of Central South University ( Site 0031), Changsha

430000

COMPLETED

Tongji Hospital Tongji Medical,Science & Technology-oncology ( Site 0018), Wuhan

430022

RECRUITING

Wuhan Union Hospital Cancer Center-Cancer Center ( Site 0008), Wuhan

450000

RECRUITING

Henan Cancer Hospital-henan cancer hospital ( Site 0015), Zhengzhou

510060

RECRUITING

Sun Yat-sen University Cancer Center ( Site 0047), Guangzhou

510080

RECRUITING

Guangdong Provincial People's Hospital ( Site 0035), Guangzhou

RECRUITING

The First Affiliated Hospital, Sun Yat-sen University ( Site 0014), Guangzhou

510655

RECRUITING

The Sixth Affiliated Hospital of Sun Yat-sen University-Oncology ( Site 0048), Guangzhou

515041

COMPLETED

Cancer Hospital of Shantou University Medical College ( Site 0036), Shantou

530200

RECRUITING

Guangxi Medical University Affiliated Tumor Hospital ( Site 0039), Nanning

610041

RECRUITING

Sichuan Cancer Hospital. ( Site 0050), Chengdu

610066

RECRUITING

West China Hospital, Sichuan University ( Site 0044), Chengdu

650106

RECRUITING

Yunnan Province Cancer Hospital-Colorectal surgery ( Site 0006), Kunming

710038

RECRUITING

Tangdu Hospital of Fourth Military Medical University of Chi-General Surgery ( Site 0045), Xi'an

830000

RECRUITING

The Affiliated Cancer Hospital of Xinjiang Medical University ( Site 0049), Ürümqi

030000

RECRUITING

Shanxi Cancer Hospital ( Site 0032), Taiyuan

Unknown

COMPLETED

Tianjin Medical University Cancer Institute and Hospital-Gastric oncology ( Site 0019), Tianjin

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY