36
Participants
Start Date
November 17, 2021
Primary Completion Date
October 31, 2025
Study Completion Date
October 31, 2027
Tumor-associated antigen-specific T cell (TAA-T)
"Patients will receive an infusion of partially HLA-matched TAA-T any time \>1 week after completing most recent course of conventional (non-investigational) therapy for their disease. For the lymphodepletion cohort, patients will receive lymphodepletion (LD) chemotherapy \>2 weeks from most recent course of conventional therapy and will nadir and recover before beginning TAA-T therapy. Patients will be enrolled to one of the following TAA-T dose levels:~BSA \<1.20 BSA ≥1.20 Dose level 1 without LD (low dose) 2x107 cells 4x107 cells Dose level 2 (LD + Low dose) 2x107 cells 4x107 cells Dose level 3 (LD + High dose) 4x107 cells 8x107 cells"
RECRUITING
Children's National Hospital, Washington D.C.
Lead Sponsor
Children's National Research Institute
OTHER