Herombopag for Chemotherapy-induced Thrombocytopenia

PHASE2RecruitingINTERVENTIONAL
Enrollment

50

Participants

Timeline

Start Date

March 14, 2022

Primary Completion Date

December 31, 2024

Study Completion Date

December 31, 2025

Conditions
Chemotherapy-induced ThrombocytopeniaHerombopag
Interventions
DRUG

Herombopag

The subjects will initiate treatment with 7.5 mg/d Herombopag. Platelet counts is obtained weekly and dose adjustment should be done according to platelet counts, and maximum dose should not exceed 7.5 mg daily. Subjects whose platelet count ≤100×109/L,the Herombopag dose will maintain. If platelet count \>100×109/L for 2 weeks, the subjects need to reduce the dose of Herombopag to the next lower dose or lower frequency. If subjects whose platelet count exceeds 100×109/L for 4 weeks,already have reduced the dose of Herombopag to 2.5mg once every other day or lower frequency during the treatment period, Herombopag can be stopped for observation, until platelet counts fall below 100×109/L. If the subjects do not need further chemotherapy or radiotherapy, the subjects can taper off Herombopag if the platelet is greater than 50×109/L.

Trial Locations (1)

300020

RECRUITING

Chinese Academy of Medical Science and Blood Disease Hospital, Tianjin

All Listed Sponsors
collaborator

Tianjin Medical University Cancer Institute and Hospital

OTHER

collaborator

Tianjin Medical University Second Hospital

OTHER

collaborator

Tianjin Third Central Hospital

OTHER

collaborator

Tianjin People's Hospital

OTHER

collaborator

Henan Cancer Hospital

OTHER_GOV

collaborator

The Second Affiliated Hospital of Kunming Medical University

OTHER

lead

Institute of Hematology & Blood Diseases Hospital, China

OTHER