NCT05224401View on ClinicalTrials.gov

Pivmecillinam With Amoxicillin/Clavulanic Acid for Step Down Oral Therapy in ESBL UTIs

PHASE3RecruitingINTERVENTIONAL
Enrollment

330

Participants

Timeline

Start Date

May 29, 2023

Primary Completion Date

September 1, 2027

Study Completion Date

September 1, 2027

Conditions
Urinary Tract InfectionsBacteremiaAntibiotic Resistant Infection
Interventions
DRUG

Pivmecillinam and amoxicillin/clavulanic acid

1 tablet pivmecillinam 400 mg and 1 tablet Amoxicillin/clavulanic acid 875/125 mg, three times daily.

DRUG

Standard treatment, ciprofloxacin, trimethoprim/sulfamethoxazole or ertapenem depending on susceptibility

Ciprofloxacin 500 mg twice daily, trimethoprim/sulfamethoxazole 800 mg/160 mg twice daily or ertapenem 1 g once daily.

Trial Locations (5)

Unknown

RECRUITING

Helsingborg hospital, Helsingborg

RECRUITING

Kristianstad hospital, Kristianstad

RECRUITING

Skåne University Hospital, Lund, Lund

RECRUITING

Skåne University Hospital, Malmö, Malmo

RECRUITING

Västmanland hospital Västerås, Västerås

All Listed Sponsors
lead

Lund University

OTHER