122
Participants
Start Date
April 12, 2022
Primary Completion Date
April 8, 2024
Study Completion Date
May 19, 2024
Delamanid + Bedaquiline + OPC-167832 10 mg
Delamanid (300 mg QD) + Bedaquiline (400 mg QD x 2 weeks, then 200 mg TIW) + OPC-167832 (10 mg QD) for 17 weeks
Delamanid + Bedaquiline + OPC-167832 30 mg
Delamanid (300 mg QD\] + Bedaquiline (400 mg QD x 2 weeks, then 200 mg TIW) + OPC-167832 (30 mg QD) for 17 weeks
Delamanid + Bedaquiline + OPC-167832 90 mg
Delamanid (300 mg QD) + Bedaquiline (400 mg QD x 2 weeks, then 200 mg TIW) + OPC-167832 (90 mg QD) for 17 weeks
RHEZ
RHEZ for 8 weeks followed by 18 weeks of rifampin and isoniazid (for a total of 26 weeks)
Aurum Institute - Tembisa Clinical Research Centre, Tembisa
Themba Lethu Clinic Clinical HIV Research Unit (CHRU), Johannesburg
Perinatal HIV Research Unit Tshepong Hospital Complex, Klerksdorp
TASK Applied Science, Brooklyn Chest Hospital Premises, Cape Town
University of CapeTown Lung Center Institute, Cape Town
Setshaba Research Center, Pretoria
Bill and Melinda Gates Foundation
OTHER
Otsuka Pharmaceutical Development & Commercialization, Inc.
INDUSTRY