930
Participants
Start Date
December 8, 2021
Primary Completion Date
April 30, 2027
Study Completion Date
April 30, 2027
RLY-2608
RLY-2608 is a mutant-selective, oral PI3Kα inhibitor.
Fulvestrant
500 mg fulvestrant is administered intramuscularly on Cycle 1 Day 1, Day 15, and Day 1 of each subsequent cycle (where a cycle is 28 days).
Palbociclib 125mg
125mg palbociclib is taken orally once daily for 28-day cycles that include 21 days of treatment followed by 7 days off treatment.
Ribociclib 400mg
400mg ribociclib is taken orally once daily for 28-day cycles that include 21 days of treatment followed by 7 days off treatment.
Ribociclib 600mg
600mg ribociclib is taken orally once daily for 28-day cycles that include 21 days of treatment followed by 7 days off treatment.
PF-07220060 100mg
PF-07220060 100 mg is taken orally twice daily at the same time with RLY-2608 during each 28-day cycle.
PF-07220060 300 mg
PF-07220060 300 mg is taken orally twice daily at the same time with RLY-2608 during each 28-day cycle.
RECRUITING
St Vincents Hospital, Sydney
RECRUITING
Peter MacCallum Cancer Center, Melbourne
RECRUITING
The Alfred Hospital, Melbourne
RECRUITING
NYU Langone, New York
RECRUITING
Columbia University Herbert Irving Comprehensive Cancer Center, New York
RECRUITING
Memorial Sloan Kettering, New York
RECRUITING
Istituto Europeo di Oncologia IRCCS, Milan
RECRUITING
Inova Schar Cancer Center, Fairfax
RECRUITING
NEXT Virginia, Fairfax
RECRUITING
START Madrid - Hospital Fundacion Jimenez Diaz, Madrid
RECRUITING
Hospital Universitario 12 de Octubre, Madrid
RECRUITING
Florida Cancer Specialists, Orlando
RECRUITING
Institute Bergonié, Bordeaux
WITHDRAWN
Boca Raton Clinical Research (BRCR) Global, Plantation
RECRUITING
Tennessee Oncology, Nashville
RECRUITING
Instituto Valenciano de Oncologia, Valencia
RECRUITING
Community Health Network, Indianapolis
RECRUITING
University of Michigan, Ann Arbor
RECRUITING
UW Carbone Cancer Center, Madison
RECRUITING
University of Chicago Medical Center, Chicago
RECRUITING
Washington University School of Medicine St. Louis, St Louis
RECRUITING
Centre Léon Bérard, Lyon
RECRUITING
University of Texas Southwestern Medical Center, Dallas
RECRUITING
The University of Texas M.D. Anderson Cancer Center, Houston
RECRUITING
HealthONE, Denver
RECRUITING
University of Utah- Huntsman Cancer Center, Salt Lake City
RECRUITING
The University of Arizona Cancer Center, Tucson
RECRUITING
Renown Regional Medical Center, Reno
RECRUITING
University of California-San Diego, San Diego
RECRUITING
Gustave Roussy, Villejuif
RECRUITING
Yale University, New Haven
RECRUITING
Massachusetts General Hospital, Boston
RECRUITING
Dana-Farber Cancer Institute, Boston
RECRUITING
Rutgers University, New Brunswick
RECRUITING
Vall d'Hebron Instituto de Oncologia, Barcelona
RECRUITING
START Barcelona, Barcelona
RECRUITING
Institut Catala D'Oncologia - Badalona (ICO Badalona), Barcelona
Relay Therapeutics, Inc.
INDUSTRY