Liver Magnetic Resonance Imaging Before Treatment for Rectal Cancer. A Randomised Controlled Trial.

NARecruitingINTERVENTIONAL
Enrollment

400

Participants

Timeline

Start Date

April 12, 2022

Primary Completion Date

December 31, 2027

Study Completion Date

December 31, 2029

Conditions
Rectal Cancer
Interventions
RADIATION

Abbreviated MRI of the liver/abdomen

"The MRI examinations of the liver/abdomen will be performed at the same time as the pelvic MRI. A 1,5 T scanner will be used together with a dedicated torso/abdominal coil. An abbreviated MRI liver protocol includes 3 different sequences as follows:~1. Axial T2-weighted respiratory triggered sequence with 5 mm slice thickness.~2. Axial diffusion weighted spin echo respiratory triggered sequence with fatsat with b-factors 50/800 s/mm2 and ADC calculation maps, 5 mm slice thickness~3. An axial breath-hold 3D T1-weighted gradient echo with fatsat with 4 mm slice thickness, gap 2 mm, contrast enhanced venous phase and in a 3 min equilibrium phase, using regular i.v bolus injection of gadolinium contrast medium with standard clinical dose."

RADIATION

Combined single venous and 3 min equilibrium phase CT of the abdomen/liver

The CT examination of the liver will be performed as a combined examination in a single venous phase starting with the thoracic region directly followed by the abdomen down to the pelvis. An additional 3 min equilibrium phase of the liver only will end the examination. Regular iodinated low-osmolar non-ionic contrast media will be used of 350 mg I/ml using a power injector, 2-4 ml/s, 100-150 ml dependent on patient weight and kidney function. Reconstructed images in axial, coronal and sagittal plane will be performed.

Trial Locations (1)

Unknown

RECRUITING

Sahlgrenska University Hospital/Östra, Gothenburg

All Listed Sponsors
lead

Vastra Gotaland Region

OTHER_GOV