Study of Fully Human B7H3 CAR-T in Treating Recurrent Malignant Ovarian Cancer

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

15

Participants

Timeline

Start Date

November 16, 2021

Primary Completion Date

August 31, 2023

Study Completion Date

August 31, 2026

Conditions
Ovarian Cancer
Interventions
BIOLOGICAL

fhB7H3.CAR-Ts

"Three dose levels will be evaluated: Dose Level 1 (1×10\^6/kg), dose Level 2 (3×10\^6/kg) and dose Level 3 (5×10\^6/kg). If dose limiting toxicities (DLTs) are observed in each doses, Dose Level -1 (0.5×10\^6/kg /infusion) will be evaluated.~Other Name: B7H3 targeting chimeric antigen receptor T cells Drug: Fludarabine 30 mg/m2 i.v. for 3 consecutive days (Day -5\~Day -3) Other Name: FLUDARA Drug: Cyclophosphamide 750 mg/m2 i.v. for once (Day -5) Other Name: Cytoxan"

Trial Locations (1)

221002

RECRUITING

The Affiliated Hospital of Xuzhou Medical University, Xuzhou

All Listed Sponsors
collaborator

Xuzhou Medical University

OTHER

collaborator

IIT MediTech (Jiangsu) Co. Ltd

UNKNOWN

lead

The Affiliated Hospital of Xuzhou Medical University

OTHER