A Study of a Mean Pulmonary Artery Pressure-Targeted Approach With Early and Rapid Treprostinil Therapy to Reverse Right Ventricular Remodeling in Participants With Pulmonary Arterial Hypertension

PHASE4Active, not recruitingINTERVENTIONAL
Enrollment

52

Participants

Timeline

Start Date

October 20, 2022

Primary Completion Date

April 30, 2026

Study Completion Date

April 30, 2028

Conditions
Pulmonary Arterial Hypertension
Interventions
DRUG

Parenteral Treprostinil

Parenteral treprostinil will be administered per schedule specified in the arm description.

DRUG

Oral Treprostinil

Oral treprostinil will be administered per schedule specified in the arm description.

Trial Locations (28)

14623

University of Rochester Medical Center, Rochester

19140

Temple Hospital, Philadelphia

24014

Carilion Clinic, Roanoke

27599

University of North Carolina at Chapel Hill, Chapel Hill

27710

Duke University Medical Center, Durham

29425

Medical University of South Carolina, Charleston

29605

Prisma Health, Greenville

30106

Georgia Clinical Research, Austell

33606

USF, Tampa

43210

The Ohio State University Wexner Medical Center, Columbus

45267

University of Cincinnati, Cincinnati

46202

Indiana University Health North Hospital, Indianapolis

46219

Community Health Network, Indianapolis

48202

Henry Ford Health System, Detroit

60611

Northwestern Memorial Hospital, Chicago

68198

University of Nebraska Medical Center, Omaha

73112

Integris Baptist Medical Center, Oklahoma City

74104

Oklahoma Heart Institute, Tulsa

75390

UT Southwestern Medical Center, Dallas

85006

Banner University Medical Center (University of Arizona), Phoenix

85020

HonorHealth John C. Lincoln Medical Center, Phoenix

90048

Cedars-Sinai Medical Center, Los Angeles

93701

University of California San Francisco - Fresno, Fresno

94143

University of California San Francisco Pulmonary, Critical Care, Allergy and Sleep Medicine, San Francisco

95817

University of California Davis Medical Center, Sacramento

06106

Hartford Hospital, Hartford

02115

Brigham and Women's Hospital, Boston

07960

Morristown Medical Center, Morristown

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Lung Biotechnology PBC

INDUSTRY

lead

United Therapeutics

INDUSTRY

NCT05203510 - A Study of a Mean Pulmonary Artery Pressure-Targeted Approach With Early and Rapid Treprostinil Therapy to Reverse Right Ventricular Remodeling in Participants With Pulmonary Arterial Hypertension | Biotech Hunter | Biotech Hunter