720
Participants
Start Date
April 1, 2022
Primary Completion Date
March 1, 2025
Study Completion Date
June 1, 2025
Oral fluoroquinolones (most commonly, ciprofloxacin) or oral trimethoprim-sulfamethoxazole
Clinically stable / non-critically ill inpatients with uncomplicated Gram-negative bacteraemia randomised to the intervention arm will be switched early to oral antibiotics (within 72 hours from index blood culture collection)
Standard of care intravenous antibiotics (e.g. ceftriaxone, cefazolin)
Clinically stable / non-critically ill inpatients with uncomplicated Gram-negative bacteraemia randomised to the standard arm will continue to receive an active intravenous antibiotic therapy for at least another 24 hours post-randomisation before clinical re-assessment and decision making by the treating doctor
RECRUITING
Tan Tock Seng Hospital, Singapore
Singapore Clinical Research Institute, Singapore
UNKNOWN
National University Hospital, Singapore
OTHER
Singapore General Hospital
OTHER
Changi General Hospital
OTHER
Ng Teng Fong General Hospital, Singapore
UNKNOWN
Sengkang General Hospital, Singapore
UNKNOWN
Royal Brisbane and Women's Hospital, Australia
UNKNOWN
Royal Melbourne Hospital, Australia
UNKNOWN
University Malaya Medical Centre, Malaysia
UNKNOWN
Samsung Medical Center, South Korea
UNKNOWN
Princess Alexandra Hospital, Australia
UNKNOWN
Gold Coast University Hospital, Australia
UNKNOWN
Ampang Hospital, Malaysia
UNKNOWN
Sungai Buloh Hospital, Malaysia
UNKNOWN
Universiti Kebangsaan Medical Centre, Malaysia
UNKNOWN
Medipol Mega University Hospital, Turkey
UNKNOWN
Rambam Hospital, Israel
UNKNOWN
Sheba Medical Centre, Israel
UNKNOWN
IRCCS Policlinico di Sant'Orsola, University Alma Mater Studiorum of Bologna, Italy
UNKNOWN
Monaldi Hospital, Italy
UNKNOWN
University Hospital of Pisa, Italy
UNKNOWN
IRCCS San Raffaele
OTHER
University General Hospital of Patras, Greece
UNKNOWN
Hospital del Mar, Parc de Salut MAR, Spain
UNKNOWN
American University of Beirut Medical Center
OTHER
Tan Tock Seng Hospital
OTHER