Study of Oral Epigallocatechin-3-gallate (EGCG) in IPF Patients

PHASE1RecruitingINTERVENTIONAL
Enrollment

50

Participants

Timeline

Start Date

August 24, 2023

Primary Completion Date

April 21, 2026

Study Completion Date

April 21, 2026

Conditions
Idiopathic Pulmonary Fibrosis
Interventions
COMBINATION_PRODUCT

EGCG 300 mg + Nintedanib

"Dietary Supplement: EGCG Capsules with Teavigo EGCG (at least 94% purity). 300 mg EGCG (2 capsules) taken orally daily for 12 weeks.~Drug: Nintedanib"

COMBINATION_PRODUCT

EGCG 300 mg + Pirfenidone

"Dietary Supplement: EGCG Capsules with Teavigo EGCG (at least 94% purity). 300 mg EGCG (2 capsules) taken orally daily for 12 weeks.~Drug: Pirfenidone"

COMBINATION_PRODUCT

Placebo 2 capsules + Nintedanib or Pirfenidone

"Dietary Supplement: Placebo Placebo (2 capsules) taken orally daily for 12 weeks.~Drug: Nintedanib~Drug: Pirfenidone"

COMBINATION_PRODUCT

EGCG 600 mg + Nintedanib

"Dietary Supplement: EGCG Capsules with Teavigo EGCG (at least 94% purity). 600 mg EGCG (2 capsules) taken orally daily for 12 weeks.~Drug: Nintedanib"

COMBINATION_PRODUCT

EGCG 600 mg + Pirfenidone

"Dietary Supplement: EGCG Capsules with Teavigo EGCG (at least 94% purity). 600 mg EGCG (2 capsules) taken orally daily for 12 weeks.~Drug: Pirfenidone"

COMBINATION_PRODUCT

Placebo 4 capsules + Nintedanib or Pirfenidone

"Dietary Supplement: Placebo Placebo (4 capsules) taken orally daily for 12 weeks.~Drug: Nintedanib~Drug: Pirfenidone"

Trial Locations (7)

10065

RECRUITING

Weill Cornell Medicine, New York

19140

RECRUITING

Temple University, Philadelphia

22908

NOT_YET_RECRUITING

University of Virginia, Charlottesville

48109

RECRUITING

University of Michigan, Ann Arbor

94143

RECRUITING

UCSF Parnassus, San Francisco

98195

RECRUITING

University of Washington, Seattle

02114

RECRUITING

Massachusetts General Hospital, Boston

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

University of Michigan

OTHER

collaborator

Cornell University

OTHER

collaborator

Massachusetts General Hospital

OTHER

collaborator

Temple University

OTHER

collaborator

University of Washington

OTHER

collaborator

University of Virginia

OTHER

lead

Hal Chapman

OTHER

NCT05195918 - Study of Oral Epigallocatechin-3-gallate (EGCG) in IPF Patients | Biotech Hunter | Biotech Hunter