Recombinant Humanized Anti-CD47/PD-1 Bifunctional Antibody HX009 in Patients With Relapsed/Refractory Lymphoma

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

99

Participants

Timeline

Start Date

December 31, 2021

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2026

Conditions
Relapsed/Refractory Lymphoma
Interventions
DRUG

Recombinant humanized anti-CD47/PD-1 bifunctional antibody HX009 injection

There will be a total of 4 cohorts, each cohort will explore 1-2 dose levels, i.e. 10 mg/kg and 15 mg/kg, with an expected enrollment of 40-80 cases. The 10 mg/kg dose level will be enrolled first, the After discussion between the sponsor and the DSC, the 15 mg/kg dose level will be enrolled if necessary. Based on the DMC analysis, the no-trend cohort will be enrolled in a maximum of 10 cases (with the possibility of stopping enrollment halfway through).

Trial Locations (1)

Unknown

RECRUITING

Cancer Hospital Chinese Academy of Medical Sciense, Beijing

All Listed Sponsors
lead

Hangzhou Hanx Biopharmaceuticals, Ltd.

INDUSTRY

NCT05189093 - Recombinant Humanized Anti-CD47/PD-1 Bifunctional Antibody HX009 in Patients With Relapsed/Refractory Lymphoma | Biotech Hunter | Biotech Hunter