CA-4948 in Combination With FOLFOX/PD-1 Inhibitor +/- Trastuzumab for Untreated Unresectable Gastric and Esophageal Cancer

PHASE1RecruitingINTERVENTIONAL
Enrollment

42

Participants

Timeline

Start Date

June 2, 2023

Primary Completion Date

September 30, 2027

Study Completion Date

June 30, 2028

Conditions
Gastric CancerEsophageal CancerStomach CancerEsophagus CancerGastroesophageal Junction Cancer
Interventions
DRUG

CA-4948

Provided by Curis, Inc.

BIOLOGICAL

Nivolumab

240 mg IV on Day 1 of each cycle

BIOLOGICAL

Pembrolizumab

400 mg IV on Day 1 of every 3 cycles (C1D1, C4D1, C7D1,…) and dosing may continue for a max of 2 years

DRUG

Trastuzumab

6 mg/kg IV loading dose on Cycle 1 Day 1 and 4 mg/kg IV on Day 1 of every subsequent cycle

DRUG

mFOLFOX7

Standard of care

Trial Locations (1)

63110

RECRUITING

Washington University School of Medicine, St Louis

All Listed Sponsors
collaborator

Curis, Inc.

INDUSTRY

collaborator

The Foundation for Barnes-Jewish Hospital

OTHER

lead

Washington University School of Medicine

OTHER