FT576 in Subjects With Multiple Myeloma

PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

31

Participants

Timeline

Start Date

November 10, 2021

Primary Completion Date

September 30, 2024

Study Completion Date

February 29, 2040

Conditions
Multiple MyelomaMyeloma
Interventions
DRUG

FT576 (Allogenic CAR NK cells with BCMA expression)

Experimental Interventional Therapy: FT576 comprises allogeneic natural killer (NK) cells, derived from a clonal, CD38-knockout, human-induced pluripotent stem cell line (iPSC) that expresses anti-B-cell maturation antigen (BCMA) chimeric antigen receptor (CAR), high-affinity, non-cleavable CD16 (hnCD16), and IL-15/IL-15 receptor fusion protein (IL-15RF).

DRUG

Cyclophosphamide

Conditioning Agent

DRUG

Fludarabine

Conditioning Agent

DRUG

Daratumumab

Anti-CD38 Monoclonal Antibody

DRUG

Bendamustine

Conditioning Agent

Trial Locations (14)

14263

Roswell Park, Buffalo

19713

Medical Oncology Hematology Consultants, Newark

23502

Virginia Oncology Associates, Norfolk

28204

Levine Cancer Institute, Charlotte

35205

University of Alabama at Birmingham, Birmingham

37203

Tennessee Oncology - Nashville, Nashville

45226

Oncology Hematology Care, Inc, Cincinnati

46202

Indiana University, Indianapolis

53226

Medical College of Wisconsin, Milwaukee

55108

University of Minnesota, Saint Paul

63130

Washington University, St Louis

75230

Texas Oncology-Medical City Dallas, Dallas

80218

Scri-Cbci, Denver

91010

City of Hope, Duarte

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Fate Therapeutics

INDUSTRY

NCT05182073 - FT576 in Subjects With Multiple Myeloma | Biotech Hunter | Biotech Hunter