A Live Recombinant Newcastle Disease Virus-vectored COVID-19 Vaccine Phase 1 Study.

PHASE1CompletedINTERVENTIONAL
Enrollment

35

Participants

Timeline

Start Date

February 9, 2022

Primary Completion Date

May 3, 2023

Study Completion Date

April 19, 2024

Conditions
SARS-CoV-2
Interventions
DRUG

Sodium Chloride

Administered intranasal (IN) and intramuscular (IM) in combination

BIOLOGICAL

NDV-HXP-S IN low dose

"Allantoic fluid diluted in Phosphate buffered saline (PBS), to be further diluted to dose strength in sodium chloride.~Strength: 3.3x108\^8 EID50."

BIOLOGICAL

NDV-HXP-S IM low dose

"Allantoic fluid diluted in Phosphate buffered saline (PBS), to be further diluted to dose strength in sodium chloride.~Strength: 3.3x10\^8 EID50."

BIOLOGICAL

NDV-HXP-S IN high dose

Allantoic fluid diluted in Phosphate buffered saline (PBS). Strength: 1x10\^9 EID50.

BIOLOGICAL

NDV-HXP-S IM high dose

Allantoic fluid diluted in Phosphate buffered saline (PBS). Strength: 1x10\^9 EID50.

Trial Locations (1)

10029

Icahn School of Medicine at Mount Sinai, New York

All Listed Sponsors
lead

Sean Liu

OTHER