Treatment of Atezolizumab and Derazantinib in Patients With Advanced iCCA With FGFR2 Fusions/Rearrangements

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

27

Participants

Timeline

Start Date

April 20, 2022

Primary Completion Date

December 31, 2025

Study Completion Date

August 31, 2026

Conditions
Intrahepatic Cholangiocarcinoma
Interventions
DRUG

Atezolizumab

Infusion i.v. of atezolizumab on day 1 of a 3-week cycle, first infusion rate over 60 minutes, subsequent infusion rates 30 minutes if tolerated for a maximum of 20 cycles in total

DRUG

Derazantinib

Oral intake of 300 mg derazantinib continuously on day 1 to day 21 of a 3-week cycle for a maximum of 20 cycles in total

Trial Locations (17)

Unknown

HELIOS KLinikum Bad Saarow, Bad Saarow

MVZ am Oskar-Helene Heim Berlin, Berlin

Universitätsmedizin Berlin Charité, Berlin

Vivantes Klinikum Berlin Friedrichshain, Berlin

Johanniter Krankenhaus Bonn, Bonn

Uniklinikum Köln, Cologne

Klinikum Esslingen, Esslingen am Neckar

Krankenhaus Nordwest gGmbH, Frankfurt

Medizinische Hochschule Hannover, Hanover

Alexianer Krefeld GmbH, Krefeld

Universitätsklinikum Leipzig, Leipzig

Universitätsmedizin Mainz, Mainz

Universitätsmedizin Mannheim, Mannheim

LMU München Großhadern, Munich

Klinikum rechts der Isar, Technische Universität München, München

Universitätsklinikum Tübingen, Tübingen

Marienhospital Wesel, Wesel

All Listed Sponsors
lead

Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest

OTHER