Loxenatide Plus LNG-IUS in Endometrial Atypical Hyperplasia

PHASE2/PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

January 8, 2022

Primary Completion Date

December 30, 2024

Study Completion Date

June 30, 2026

Conditions
Atypical Endometrial HyperplasiaObesityFertility Issues
Interventions
DEVICE

levonorgestrel-releasing intrauterine system

Enrolled patients will be inserted this device for treating AEH to preserve fertility for 3-6 months or longer till complete response or operation if treatment fails, and the device may be removed if treatment changes.

DRUG

Polyethylene Glycol Loxenatide

Initiate injection of Loxenatide will be 0.1mg per week, if the patient can tolerate, the dose will be increased to 0.2mg per week, or else 0.1mg per week will be injected and the injection will last for no more than 28 weeks. If the patient cannot tolerate the least 0.1mg/week, she must be excluded from this trial.

Trial Locations (1)

200090

Obstetrics & Gynecology Hospital of Fudan University, Shanghai

All Listed Sponsors
lead

Fudan University

OTHER