121
Participants
Start Date
October 26, 2022
Primary Completion Date
March 7, 2027
Study Completion Date
March 7, 2029
SC Mosunetuzumab
Participants will receive SC mosunetuzumab for 12 cycles (cycle length = 21 days or 28 days for Cycle 1 and 28 days for Cycles 2-12)
IV Glofitamab
Participants will receive IV glofitamab for 12 cycles (cycle length = 21 days)
Iberdomide
Arm 1: Participants will receive oral CC-220 from Day 1-21 of Cycle 2-12 (cycle length = 28 days for Cycles 2-12)
Golcadomide
Arm 1: Participants will receive oral golcadomide from Day 1-14 starting in either Cycle 1 or Cycle 2 through Cycle 12 (cycle length = 28 days for cycles when golcadomide is to be administered) Arm 2: Participants will receive oral golcadomide from Day 1-10 starting in either Cycle 1, Cycle 2 or Cycle 3 through Cycle 12 (cycle length = 21 days)
Obinutuzumab
Participants in Arm 2 will receive pre-treatment with IV obinutuzumab on Cycle 1 Day 1 (cycle length = 21 days)
Tocilizumab
Participants will receive IV tocilizumab as needed to manage cytokine release syndrome (CRS)
RECRUITING
Irccs Ospedale San Raffaele, Milan
RECRUITING
ASST Spedali Civili di Brescia, Brescia
RECRUITING
Clinica Universidad de Navarra-Madrid, Madrid
RECRUITING
Hospital General Universitario Gregorio Maranon, Madrid
RECRUITING
Levine Cancer Institute, Charlotte
RECRUITING
Moffitt Cancer Center, Tampa
RECRUITING
Hosp Universitario Salamanca, Salamanca
RECRUITING
IRCCS Azienda Ospedaliero Universitaria di Bologna, Bologna
RECRUITING
Hospital Universitario La Fe, Valencia
RECRUITING
"IRCCS Istituto Romagnolo per lo studio dei tumori Dino Amadori", Meldola
RECRUITING
Azienda Ospedaliero Universitaria Pisana-Ospedale Santa Chia, Pisa
RECRUITING
The University of Chicago, Chicago
RECRUITING
UT MD Anderson Cancer Center, Houston
RECRUITING
University of Colorado, Aurora
RECRUITING
UCSF/Hematology, Blood & Marrow Transplant, And Cellular Therapy (HBC) Program, San Francisco
RECRUITING
Rambam Health Care Campus, Haifa
RECRUITING
Center Hospital, Ramat Gan
RECRUITING
Sourasky Medical Center, Tel Aviv
RECRUITING
Hadassah Medical Center, Jerusalem
RECRUITING
Soroka, Beersheba
RECRUITING
ICO L'Hospitalet, L'Hospitalet de Llobregat
RECRUITING
Hospital Universitari Vall d Hebron, Barcelona
RECRUITING
NHS Greater Glasgow and Clyde, Glasgow
RECRUITING
University College London Hospitals, London
RECRUITING
Nottingham University Hospitals City Campus, Nottingham
RECRUITING
Oxford University Hospitals NHS Trust;Churchill Hospital, Oxford
Hoffmann-La Roche
INDUSTRY