Therapeutic Cancer Vaccine (AST-301, pNGVL3-hICD) in Patients With Breast Cancer

PHASE2TerminatedINTERVENTIONAL
Enrollment

10

Participants

Timeline

Start Date

February 28, 2022

Primary Completion Date

May 31, 2024

Study Completion Date

May 31, 2024

Conditions
Breast Cancer
Interventions
BIOLOGICAL

AST-301(pNGVL3-hICD)

Q3W, 3 cycles, Plus a booster at 24 weeks post the third vaccination, Intradermal injection

DRUG

rhuGM-CSF

Q3W, 3 cycles, Plus a booster at 24weeks post the third vaccination, Intradermal injection

DRUG

Placebo

Q3W, 3 cycles, Plus a booster at 24 weeks post the third vaccination, Intradermal injection

DRUG

Pembrolizumab

Q3W; IV infusion

DRUG

Capecitabine

On days 1-14 (Q3W), BID ; Oral administration,

Trial Locations (17)

112

National Taiwan University Hospital, Taipei

Taipei Veterans General Hospital, Taipei

404

China Medical University Hospital, Taichung

500

Changhua Christian Hospital, Changhua

710

Chi Mei Medical Center, Tainan City

11259

Koo Foundation Sun Yat-Sen Cancer Center, Taipei

33612

Moffitt Cancer Center, Tampa

43623

The Ohio State University Comprehensive Cancer Center, Columbus

Toledo Clinic Cancer Center, Toledo

44718

Gabrail Cancer Center Research, Canton

60612

University of Illinois Cancer Center, Chicago

68130

Nebraska Cancer Specialist, Omaha

80756

Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City

85224

Ironwood Cancer and Research Centers, Chandler

92037

Scripps Health, La Jolla

97213

Providence Cancer Institute, Portland

98109

University of Washington, Seattle

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Aston Sci. Inc.

INDUSTRY

NCT05163223 - Therapeutic Cancer Vaccine (AST-301, pNGVL3-hICD) in Patients With Breast Cancer | Biotech Hunter | Biotech Hunter