S095029 as Monotherapy and in Combination With Sym021 in Patients With Advanced Solid Tumor Malignancies Followed by an Expansion Part With Triple Combinations in Patients With Metastatic Gastric or Colorectal Cancers

PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

51

Participants

Timeline

Start Date

October 15, 2021

Primary Completion Date

February 1, 2024

Study Completion Date

June 19, 2025

Conditions
Solid Tumor
Interventions
DRUG

S095029

S095029 will be administered via IV infusion every 2 weeks. Once the DLT evaluations period at the second dose level is completed and it is deemed as safe, the dose escalation part 1b will be initiated.

DRUG

S95029 and Sym021

Sym021 will be administered at a fixed dose of 200mg. S095029 will be administered via IV infusion every 2 weeks. Once the RP2D dose of S95029 in combination with Sym21 is defined, dose expansion will begin.

Trial Locations (5)

49546

START Midwest, Grand Rapids

75230

Mary Crowley Cancer Research, Dallas

77030

The University of Texas MD Anderson Cancer Center, Houston

78229

The START Center for Cancer Care, San Antonio

Unknown

Princess Margaret Cancer Centre, Toronto

All Listed Sponsors
collaborator

ADIR, a Servier Group company

INDUSTRY

lead

Institut de Recherches Internationales Servier

OTHER