A Phase 3 Study to Assess the Safety and Efficacy of Pitolisant in Adult Patients With Idiopathic Hypersomnia

PHASE3CompletedINTERVENTIONAL
Enrollment

214

Participants

Timeline

Start Date

May 25, 2022

Primary Completion Date

September 8, 2023

Study Completion Date

September 8, 2023

Conditions
Idiopathic Hypersomnia
Interventions
DRUG

Open-label pitolisant

"Pitolisant 4.45 mg tablets: white, round, plain, biconvex film-coated tablet, 3.7 mm in diameter. Each tablet contains 5 mg of pitolisant hydrochloride equivalent to 4.45 mg of pitolisant.~Pitolisant 17.8 mg tablets: white, round, plain, biconvex film-coated tablet, 7.5 mm in diameter. Each tablet contains 20 mg of pitolisant hydrochloride equivalent to 17.8 mg of pitolisant."

DRUG

Double-blind placebo

Matching placebo tablets will be provided for each strength of active pitolisant film-coated tablets.

DRUG

Double-blind pitolisant

"Pitolisant 4.45 mg tablets: white, round, plain, biconvex film-coated tablet, 3.7 mm in diameter. Each tablet contains 5 mg of pitolisant hydrochloride equivalent to 4.45 mg of pitolisant.~Pitolisant 17.8 mg tablets: white, round, plain, biconvex film-coated tablet, 7.5 mm in diameter. Each tablet contains 20 mg of pitolisant hydrochloride equivalent to 17.8 mg of pitolisant."

Trial Locations (58)

11042

Northwell Health, New Hyde Park

19090

Abington Neurological Associates, Willow Grove

19301

Brian Abaluck, LLC, Paoli

19610

Respiratory Specialists, Wyomissing

20815

Helene A. Emsellem MD PC, Chevy Chase

23507

Children's Hospital of the King's Daughter, Norfolk

26506

West Virginia University - Department of Neurology, Morgantown

27705

Duke University School of Medicine, Durham

28037

Research Carolina Elite LLC, Denver

28054

Clinical Research of Gastonia, Gastonia

28078

ARSM Research, Huntersville

29201

Bogan Sleep Consultants, Columbia

29406

Lowcountry Lung Critical Care, North Charleston

29425

Medical University of South Carolina- Institute of Psychiatry, Charleston

30328

Neurotrials Research Inc., Atlanta

30501

The Neurological Center of North GA, Gainesville

32789

Florida Pediatric Research Institute, Winter Park

33126

Sleep Medicine Specialists of South Florida, PA, Miami

33511

Meris Clinical Research, Brandon

33763

Pasadena Center For Medical Research, LLC, St. Petersburg

33765

St. Francis Medical Institute, Clearwater

37421

Advanced Center for Sleep Disorders, Chattanooga

38018

Neurology Clinic, P.C., Cordova

43017

Ohio Sleep Medicine and Neuroscience Institue, Dublin

44106

Rainbow Babies Children's Hospital, Cleveland

44130

North Star Medical Research, Middleburg

44195

Cleveland Clinc, Cleveland

44718

NeuroScience Research Center, LLC, Canton

45245

Intrepid Research, LLC, Cincinnati

48314

Clinical Neurophysiology Services, Sterling Heights

48377

Henry Ford Health System, Novi

49024

Bronson Sleep Health, Portage

53719

University of Wisconsin-Madison, Madison

55125

Minnesota Lung Center, Edina

Minnesota Lung Center, Woodbury

60026

NorthShore Uni HealthSys-Glenbrook Hospital, Glenview

60611

Northwestern University, Chicago

61637

OSF HealthCare Saint Francis Medical Center, Peoria

63017

St. Luke's Sleep Medicine and Research Center, Chesterfield

63123

Clayton Sleep Institute, St Louis

69101

Great Plains Health, North Platte

73401

CardioVoyage, Ardmore

77375

Northwest Houston Neurology and Sleep, Tomball

77478

Comprehensive Sleep Medicine Associates, Sugar Land

78681

Central Texas Neurology Consultants, PA, Round Rock

78731

FutureSearch Trials of Neurology LP, Austin

80301

Alpine Clinical Research Center, Boulder

85259

Mayo Clinic, Scottsdale

85381

Phoenix Medical Group, Peoria

90048

Cedars-Sinai Medical Towers, Los Angeles

90095

University of California- Los Angeles, Los Angeles

90404

Santa Monica Clinical Trials, Santa Monica

92705

SDS Clinical Trials Inc., Santa Ana

94583

Sleep Medicine Specialists of California, San Ramon

06850

Norwalk Hospital Sleep Center, Norwalk

02115

Boston Children's Hospital, Boston

02459

Neurocare, INC, Newton

07764

Neurology Specialists of Monmouth County, PA, West Long Branch

All Listed Sponsors
lead

Harmony Biosciences Management, Inc.

INDUSTRY