Study of BMF-219, a Covalent Menin Inhibitor, in Adult Patients With AML, ALL (With KMT2A/ MLL1r, NPM1 Mutations), DLBCL, MM, and CLL/SLL

PHASE1TerminatedINTERVENTIONAL
Enrollment

55

Participants

Timeline

Start Date

January 24, 2022

Primary Completion Date

February 13, 2025

Study Completion Date

May 2, 2025

Conditions
Acute Myeloid LeukemiaAcute Lymphoblastic LeukemiaAcute Mixed-Phenotype LeukemiaCancerRefractoryProgressionDiffuse Large B Cell LymphomaMultiple MyelomaLymphomaLymphoma, Non-HodgkinMyeloma, Plasma-CellMyelomatosisPlasma Cell MyelomaChronic Lymphocytic LeukemiaSmall Lymphocytic Lymphoma
Interventions
DRUG

BMF-219

BMF-219 is orally administered in continuous 28 day cycles. Alternative BID dosage may be used.

Trial Locations (41)

10003

Hospital San Pedro de Alcántara, Cáceres

20089

Instituto Clinico Humanitas, Milan

20132

IRCCS Ospedale San Raffaele, Programma di Ricerca Strategica su LLC, Milan

20155

Virginia Cancer Specialists, Gainesville

24128

ASST Papa Giovanni XXIII Hospital Bergamo, Bergamo

28006

Hospital Universitario de la Princesa, Madrid

28040

Hospital Universitario Fundación Jiménez Díaz, Madrid

28041

Hospital Universitario 12 de Octubre, Madrid

30342

Blood & Marrow Transplant Group of GA (Northside Hospital), Atlanta

32224

Mayo Clinic, Jacksonville

33011

Hospital Universitario Central de Asturias, Oviedo

33140

Mount Sinai Medical Center, Miami Beach

33612

Moffitt Cancer Center, Tampa

37007

Hospital Universitario de Salamanca, Salamanca

37232

Vanderbilt University Medical Center, Nashville

41013

Hospital Universitario Virgen del Rocio, Seville

44195

Cleveland Clinic Foundation, Cleveland

45219

University of Cincinnati Medical Center, Cincinnati

46026

Hospital Universitario y Politécnico La Fe, Valencia

48202

Henry Ford Hospital, Detroit

60126

AOU Ospedali Riuniti Ancona, Ancona

60611

Northwestern University, Chicago

73104

University of Oklahoma Health Sciences Center, Oklahoma City

77030

MD Anderson Cancer Center, Houston

90033

University of Southern California Norris Cancer Center, Los Angeles

90095

UCLA Department of Medicine, Los Angeles

92697

University of California, Irvine, Irvine

94305

Stanford Cancer Center, Stanford

95817

UC Davis Comprehensive Cancer Center, Sacramento

106 76

Evangelismos General Hospital of Athens, Athens

115 28

Alexandra General Hospital of Athens, Athens

435 - 20141

Istituto Europeo di Oncologia, Milan

06132

Ospedale Santa Maria della Misericordia, Perugia

00168

Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma

1081HV

Amsterdam UMC, Amsterdam

9700 RB

UMCG Groningen, Groningen

6500 HB

Radboud University Medical Center, Nijmegen

3015 GD

Erasmus University Medical Center Rotterdam, Rotterdam

02006

Hospital General de Albacete, Albacete

08036

Hospital Clinic de Barcelona, Barcelona

08916

Institut Catala d'Oncologia, Barcelona

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Biomea Fusion Inc.

INDUSTRY

NCT05153330 - Study of BMF-219, a Covalent Menin Inhibitor, in Adult Patients With AML, ALL (With KMT2A/ MLL1r, NPM1 Mutations), DLBCL, MM, and CLL/SLL | Biotech Hunter | Biotech Hunter