A Study to Investigate Vamikibart (RO7200220) in Diabetic Macular Edema

PHASE2CompletedINTERVENTIONAL
Enrollment

394

Participants

Timeline

Start Date

December 31, 2021

Primary Completion Date

November 6, 2024

Study Completion Date

April 21, 2025

Conditions
Diabetic Macular Edema
Interventions
DRUG

Vamikibart

Vamikibart will be administered by IVT injection as specified in each treatment arm.

DRUG

Ranibizumab

Ranibizumab 0.5 mg will be administered to the participants by IVT injection, as specified in the treatment arm.

OTHER

Sham Procedure

Sham is a procedure that mimics an IVT injection and involves the blunt end of an empty syringe (without a needle) being pressed against the anesthetized eye. Sham procedure will be administered to participants in the Q8W arms at applicable visits to maintain masking between treatment arms.

Trial Locations (74)

11563

Opthalmic Consultants of LI, Lynbrook

13605

Seoul National University Bundang Hospital, Seongnam-si

14642

University of Rochester Flaum Eye Institute, Rochester

15143

Sewickley Eye Group, Sewickley

16507

Erie Retinal Surgery, Erie

18704

Eye Care Specialists, PC, Kingston

21740

Cumberland Valley Retina PC, Hagerstown

23502

Wagner Macula & Retina Center, Norfolk

24502

Piedmont Eye Center, Lynchburg

27157

Wake Forest Baptist Medical Center, Winston-Salem

28222

Hospital Universitario Puerta de Hierro, Majadahonda

28803

Western Carolina Retinal Associate PA, Asheville

29456

Charleston Neuroscience Institute, Ladson

33064

Rand Eye, Deerfield Beach

33544

Retina Specialists of Tampa, Wesley Chapel

33607

Retina Vitreous Associates of Florida, St. Petersburg

33912

National Ophthalmic Research Institute, Fort Myers

37203

Retina Consultants of Nashville, Nashville

38671

Deep Blue Retina PLLC, Southaven

40206

Butchertown Clinical Trials, Louisville

42415

Yeungnam University Medical Center, Daegu

45219

Meridian Clinical Research, Cincinnati

46100

Oftalvist Valencia, Burjassot

50009

Hospital Universitario Miguel Servet, Zaragoza

57701

Black Hills Eye Institute, Rapid City

75075

Texas Retina Associates, Arlington

76087

Strategic Clinical Research Group, LLC, Willow Park

77401

Retina Consultants of Texas, Bellaire

78240

Retina Consultants of Texas, The Woodlands

78503

Valley Retina Institute P.A., McAllen

78750

Austin Clinical Research LLC, Austin

80228

Colorado Retina Associates, PC, Lakewood

89502

Sierra Eye Associates, Reno

91006

Win Retina, Arcadia

92064

Retina Consultants, San Diego, Poway

94598

Bay Area Retina Associates, Walnut Creek

95825

Retinal Consultants Med Group, Sacramento

97225

EyeHealth Northwest, Portland

97401

Verum Research LLC, Eugene

20011-3010

Emerson Clinical Research Institute LLC, Washington D.C.

32806-1101

Florida Retina Institute, Orlando

C1015ABO

Organizacion Medica de Investigacion, Buenos Aires

C1116

Centro Oftalmologico Dr. Charles S.A., Capital Federal

C1120AAN

Oftalmos, Capital Federal

C1061AAE

Buenos Aires Mácula, Ciudad Autonoma Buenos Aires

Unknown

Centro Privado de Ojos Romagosa, Córdoba

Centro de ojos Loria, Lomas de Zamora

AXON Clinical, Prague

M5500GGK

Oftar, Mendoza

S2000CTC

Microcirugía Ocular S.A, Rosario

S2000DLA

Grupo Laser Vision, Rosario

K2B 7E9

Retina Institute of Ottawa, Ottawa

M3C 0G9

Toronto Retina Institute, Toronto

J7H 0E8

Institut De L'Oeil Des Laurentides, Boisbriand

708 52

Faculty Hospital Ostrava, Ostrava

100 34

Faculty Hospital Kralovske Vinohrady, Prague

128 08

General Teaching Hospital Prague, Prague

44-100

Niepubliczny Zak?ad Opieki Zdrowotnej PRYZMAT-OKULISTYKA, Gliwice

40-514

Uniwersyteckie Centrum Kliniczne, Katowice

31-070

Centrum Medyczne UNO-MED, Krakow

20-079

SPSK nr 1 w Lublinie, Lublin

10-424

Centrum Diagnostyki i Mikrochirurgii Oka LENS, Olsztyn

44-203

LensClinic, Rybnik

42-600

Caminomed, Tarnowskie Góry

00612

Emanuelli Research and Development Center LLC, Arecibo

05505

Asan Medical Center, Seoul

06351

Samsung Medical Center, Seoul

07301

Kim's Eye Hospital, Seoul

08190

Hospital General de Catalunya, Sant Cugat de Valles

BS1 2LX

Bristol Eye Hospital, Bristol

GL1 3NN

Gloucestershire Hospitals NHS Foundation Trust, Gloucestershire

GU2 7XX

Royal Surrey County Hospital, Guildford

EC1V 2PD

Moorfields Eye Hospital NHS Foundation Trust, London

NE1 4LP

Royal Victoria Infirmary, Newcastle upon Tyne

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY

NCT05151731 - A Study to Investigate Vamikibart (RO7200220) in Diabetic Macular Edema | Biotech Hunter | Biotech Hunter