RESET-psychotherapy: the Effectiveness of Trauma-focused Therapy in Patients With Depression and Childhood Trauma

NAUnknownINTERVENTIONAL
Enrollment

158

Participants

Timeline

Start Date

November 10, 2021

Primary Completion Date

March 1, 2024

Study Completion Date

March 1, 2024

Conditions
Major Depressive DisorderChildhood Trauma
Interventions
BEHAVIORAL

Treatment as usual (TAU) for depression

TAU for depression will be largely determined by the Dutch multidisciplinary practice guideline on depression (Spijker et al., 2013). This means that patients with CT-related depression will receive good clinical care, e.g. evidence-based psychotherapeutic interventions, such as cognitive behavioral therapy (CBT) or interpersonal therapy (IPT) combined with/or pharmacotherapy. Therapists who give TAU are not allowed to provide a trauma-focused intervention aimed at CT during the 12-week intervention period.

BEHAVIORAL

Trauma-focused therapy (TFT)

The content of TFT, delivered by another therapist than the therapist that will provide TAU, depends on the type of CT the patient reports. If the patient predominantly reports experiences of abuse, there are often clear memories of this abuse ('target images') present and Eye Movement Desensitization and Reprocessing (EMDR) is recommended as the treatment strategy. If the patient predominantly reports experiences of neglect, memories are often less identifiable, although these experiences can have a big impact on the development of maladaptive schemas. In this case, imagery rescripting (ImRs) is recommended as treatment strategy. If the patient reports both experiences of abuse and neglect, the therapist will discuss with the patient which type of CT has the greatest impact on the current depressive symptoms and starts with the indicated therapy. If indicated, the therapist can switch between EMDR and ImRs after a minimum of 4 sessions.

Trial Locations (3)

1081HJ

RECRUITING

GGZ inGeest, Amsterdam

3447GN

RECRUITING

HSK Groep, Woerden

3524SH

NOT_YET_RECRUITING

Altrecht, Utrecht

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Stichting tot steun VCVGZ

OTHER

collaborator

HSK Groep B.V.

UNKNOWN

collaborator

Altrecht

OTHER

lead

Amsterdam UMC, location VUmc

OTHER

NCT05149352 - RESET-psychotherapy: the Effectiveness of Trauma-focused Therapy in Patients With Depression and Childhood Trauma | Biotech Hunter | Biotech Hunter