Restrictive Vs. Liberal Oxygen in Trauma

PHASE4CompletedINTERVENTIONAL
Enrollment

1,508

Participants

Timeline

Start Date

December 10, 2021

Primary Completion Date

October 12, 2023

Study Completion Date

October 12, 2024

Conditions
TraumaOxygen ToxicityWounds and Injuries
Interventions
DRUG

Restrictive oxygen

Lowest oxygen delivery possible (≥21%) ensuring an SpO2 target = 94%

DRUG

Liberal oxygen

15 L O2/min flow for non-intubated trial participants or FiO2 = 1.0 for intubated trial participants in the initial phase; later in the operating room, intensive care unit, post-anesthesia care unit and ward, the flow/FiO2 can be reduced to ≥12 L O2/min or FiO2 ≥0.6 if the arterial oxygen saturation is ≥98%

Trial Locations (5)

2100

Rigshospitalet, Copenhagen University Hospital, Copenhagen

3000

Erasmus MC, University Medical Center Rotterdam, Rotterdam

3010

Inselspital University Hospital Bern, Bern

5000

Odense University Hospital, Odense

8200

Aarhus University Hospital, Aarhus

All Listed Sponsors
collaborator

The Novo Nordic Foundation

OTHER

lead

Rigshospitalet, Denmark

OTHER

NCT05146700 - Restrictive Vs. Liberal Oxygen in Trauma | Biotech Hunter | Biotech Hunter