Personalized Therapeutic Neuromodulation for Anhedonic Depression

NAActive, not recruitingINTERVENTIONAL
Enrollment

79

Participants

Timeline

Start Date

May 31, 2022

Primary Completion Date

March 30, 2025

Study Completion Date

June 30, 2025

Conditions
Treatment Resistant Depression
Interventions
DEVICE

Active TBS-DLPFC

"Participants in the active stimulation group will receive intermittent TBS to left DLPFC. The L-DLPFC will be targeted utilizing the Localite neuronavigation system. Stimulation intensity will be standardized at 90% of RMT and adjusted to the skull to cortical surface distance (see Nahas 2004).~Stimulation will be delivered to the L-DLPFC using a MagPro TMS system (MagVenture, Denmark)."

DEVICE

Active TBS-DMPFC

"Participants in the active stimulation group will receive intermittent TBS to DMPFC. The DMPFC will be targeted utilizing the Localite neuronavigation system. Stimulation intensity will be standardized at 90% of RMT and adjusted to the skull to cortical surface distance (see Nahas 2004).~Stimulation will be delivered to the DMPFC using a MagPro TMS system (MagVenture, Denmark)."

DEVICE

Sham TBS-DLPFC or DMPFC

The parameters in the sham arm will be as above with the internal randomization of the device internally switching to sham in a blinded fashion.

Trial Locations (1)

94305

Department of Psychiatry and Behavioral Sciences, Stanford School of Medicine, Stanford

All Listed Sponsors
lead

Stanford University

OTHER