498
Participants
Start Date
December 1, 2021
Primary Completion Date
June 30, 2029
Study Completion Date
June 30, 2031
Surgery with or without Neck Dissection
An appropriate surgery as open, endoscopic, TLM, TORS or a combination with or without neck dissection e.g. levels dissected, sparing or sacrifice of the SCM, accessory nerve, etc as per patient disease and status will be performed
Radiation
Patients will receive IMRT with normal tissue sparing techniques (70Gy/35# or 66Gy/ 30#) along with concurrent weekly cisplatin. Weekly cisplatin will be administered during IMRT at a dose of 40 mg/m2 IV on days 1, 8, 15, 22, 29, 36, and 43 for a total of upto 7 weekly doses, administered during the course of IMRT.
Cisplatin based chemotherpay
Cisplatin (dose-40 mg/m2weekly,upto6-7cycles) cycle 1 will be administered within first 2 # of radiation. The rest of the cycles will be given weekly.
Tata Memorial Hospital, Mumbai
All India Institute of Medical Sciences
OTHER
Amrita Institute of Medical Sciences & Research Center
OTHER
Tata Memorial Centre
OTHER