A Study to Assess the Hemodynamic Effects, Safety, Tolerability, and Pharmacokinetics of Intravenous APD418 in Adult Participants With Heart Failure With Reduced Ejection Fraction

PHASE2TerminatedINTERVENTIONAL
Enrollment

22

Participants

Timeline

Start Date

December 28, 2021

Primary Completion Date

September 19, 2022

Study Completion Date

September 19, 2022

Conditions
Acute Heart Failure With Reduced Ejection Fraction
Interventions
DRUG

APD418

Participants will receive a single dose of APD418 as an intravenous (IV) infusion.

DRUG

APD418

Participants will receive a single dose of APD418 as an IV infusion.

DRUG

Placebo

Participants will receive a single dose of APD418 matching placebo as an IV infusion.

Trial Locations (21)

11000

University Clinical Centre of Serbia, Belgrade

11040

Institute for Cardiovascular Diseases Dedinje, Belgrade

11080

Clinical Hospital Center Bezanijska Kosa, Belgrade

14233

Konstantinopouleio General Hospital of Nea Ionia - Patision ''Agia Olga'', Nea Ionia

16321

Immanuel Hospital Bernau Brandenburg Heart Center, Bernau bei Berlin

17475

Universitatsmedizin Greifwald, Greifswald

21204

Institute for Cardiovascular Diseases of Vojvodina, Kamenitz

31000

Healthcare Center Uzice, Užice

33612

James A. Haley Veterans' Hospital, Tampa

34000

Clinical Center of Kragujevac, Kragujevac

41110

General University Hospital of Larissa, Larissa

53792

University of Wisconsin, Madison

55535

Interbalkan European Medical Center, Pylaia

61231

Kerckhoff-Klinik Forschungsgesellschaft GmbH, Bad Nauheim

61606

UnityPoint Health - Methodist Hospital, Peoria

77030

UTHealth, Houston

84132

Health Science Center Utah, Salt Lake City

62-200

American Heart of Poland S.A., Gniezno

31-202

Krakowski Szpital Specjalistyczny im. Jana Pawla II, Krakow

50-556

Uniwersytecki Szpital Kliniczny im Jana Mikulicza-Radeckiego, Wroclaw

11 070

Clinical Hospital Centre Zemun, Belgrade

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Arena is a wholly owned subsidiary of Pfizer

INDUSTRY

lead

Pfizer

INDUSTRY