A Study of Adeno-Associated Virus Serotype 8-Mediated Gene Transfer of Glucose-6-Phosphatase in Patients With Glycogen Storage Disease Type Ia (GSDIa)

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

49

Participants

Timeline

Start Date

November 8, 2021

Primary Completion Date

February 20, 2024

Study Completion Date

February 28, 2026

Conditions
Glycogen Storage Disease Type IA
Interventions
GENETIC

DTX401

nonreplicating, recombinant, adeno-associated virus (AAV) serotype 8 (AAV8)

OTHER

Placebo

Normal Saline infusion

DRUG

Oral corticosteroids

Participants who receive DTX401 solution will receive oral corticosteroids

DRUG

Placebo for oral corticosteroids

Participants who receive Placebo will receive placebo oral corticosteroids to maintain the study blind

Trial Locations (20)

2100

Righospitalet, Copenhagen

10467

Mount Sinai, The Bronx

15706

Hospital Clinico Universitario de Santiago, Santiago de Compostela

16147

Istituto Giannina Gaslini, Genova

19104

Children's Hospital of Philadelphia, Philadelphia

20251

University Medical Center Eppendorf, Hamburg

27710

Duke University, Durham

44195

Cleveland Clinic, Cleveland

77030

University of Texas, Houston

80045

Children's Hospital Colorado, Aurora

80131

University of Naples, Naples

84132

Primary Children's Hospital, Salt Lake City

92868

Children's Hospital of Orange County, Orange

06030

University of Connecticut Health Center, Farmington

90035-903

Hospital de Clinicas de Porto Alegre, Porto Alegre

H3H 1P3

McGill University, Montreal

Unknown

Kumamoto University Hospital, Kumamoto

Osaka City General Hospital, Osaka

Fujita Health University Hospital, Toyoake

9700 RB

Groningen University, Groningen

All Listed Sponsors
lead

Ultragenyx Pharmaceutical Inc

INDUSTRY