Rituximab Therapy in Anti-Myelin Associated Glycoprotein Patients With Characteristics of Good Responders

PHASE3RecruitingINTERVENTIONAL
Enrollment

90

Participants

Timeline

Start Date

June 29, 2023

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2025

Conditions
Anti-MAG Neuropathy
Interventions
DRUG

Rituximab infusion

2 infusions of 1 gram of rituximab at a 2 week interval (day 1 followed by day 15).

DRUG

Placebo infusion

2 infusions of placebo at a 2 week interval.

DRUG

Premedications

"Premedications prior to rituximab or placebo infusions:~* IV Dexchlorpheniramine Maleate IV: 10 mg~* IV Methylprednisolone: 40 mg~* PO Paracetamol : 1 gram"

Trial Locations (15)

13915

NOT_YET_RECRUITING

CHU La Timone - APHM, Marseille

29200

NOT_YET_RECRUITING

CHU Brest - La cavale blanche, Brest

31059

NOT_YET_RECRUITING

CHU Toulouse - Pierre-Paul Riquet, Toulouse

37044

NOT_YET_RECRUITING

CHU Tours - Bretonneau, Tours

38700

NOT_YET_RECRUITING

CHU Grenoble - La tronche, Grenoble

54035

NOT_YET_RECRUITING

CHU Nancy- Hôpital central, Nancy

59037

NOT_YET_RECRUITING

CHU Lille - Roger Salengro, Lille

67091

NOT_YET_RECRUITING

CHU Strasbourg - Hautepierre, Strasbourg

69002

NOT_YET_RECRUITING

HCL lyon, Lyon

75651

NOT_YET_RECRUITING

APHP Pitié Salpêtrière, Paris

87170

NOT_YET_RECRUITING

CHU Limoges - Dupuytren, Limoges

94270

NOT_YET_RECRUITING

APHP - Kremlin-Bicêtre, Paris

Unknown

NOT_YET_RECRUITING

Hôtel-Dieu et Hôpital GR Laënnec - CHU Nantes, Nantes

RECRUITING

CHU de Saint-Etienne, Saint-Etienne

06031

NOT_YET_RECRUITING

CHU Nice - Pasteur, Nice

All Listed Sponsors
collaborator

Ministry of Health, France

OTHER_GOV

lead

Centre Hospitalier Universitaire de Saint Etienne

OTHER