Study of the Evolution of Olfactory Disorders in Patients With Persistent Loss of Smell Following COVID-19

NACompletedINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

June 20, 2022

Primary Completion Date

October 15, 2024

Study Completion Date

October 15, 2024

Conditions
SARS-CoV-2 Acute Respiratory Disease
Interventions
OTHER

Clinical examination

The investigator will conduct a clinical examination to rule out other causes of olfactory impairment independent of COVID-19. The investigator will also collect the following information: socio-demographic data (age, sex, blood type, weight, height, etc.), history of olfaction disorder symptoms, past or current treatments received and tobacco/alcohol consumption.

OTHER

Blood collection

12ml-blood sample

OTHER

Olfactory evoked potentials

Olfactory evoked potentials will be recorded during olfactory tests.

OTHER

Brushing of olfactory slits

collection of olfactory slits cells.

OTHER

Neurological examination and neuropsychological assessment

"* MOCA, BREF~* CVLT~* WAIS IV, MEM III~* Right-side and left-side empan, Trail Making Test A and B (TMT), verbal fluency tests, PASAT, Attention Assessment Test~* Benton's Line Judgement, VOSP~* Assessment of psychological status, fatigue and screening for psychiatric comorbidities: depression \& anxiety scales (HAD scale, mADRS depression scale, STAI anxiety scale), Fatigue Severity Scale."

OTHER

Nasal endoscopy

Nasal endoscopy

OTHER

Assessment of olfactory and taste functions

"* scales: VAS and TSS~* Sniffin Stick test"

Trial Locations (1)

75010

Hôpital Lariboisière, Paris

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Hopital Lariboisière

OTHER

lead

Institut Pasteur

INDUSTRY

NCT05133596 - Study of the Evolution of Olfactory Disorders in Patients With Persistent Loss of Smell Following COVID-19 | Biotech Hunter | Biotech Hunter