Neoadjuvant Folfirinox Combined With Pembrolizumab Followed by Surgery for Patients With Resectable Pancreatic Cancer

PHASE2RecruitingINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

August 31, 2022

Primary Completion Date

May 21, 2027

Study Completion Date

May 21, 2027

Conditions
Pancreatic Ductal Adenocarcinoma
Interventions
DRUG

Pembrolizumab

Pembrolizumab will be initiated starting with the Cycle 2 Day 1 and will be administered every 6 weeks with a max amount of 9 cycles throughout the study.

DRUG

Folfirinox

Once eligibility has been confirmed and the patient has been registered to the study, the patient will begin induction modified FOLFIRINOX (Oxaliplatin, Leucovorin, Irinotecan, 5-Fluorouracil) chemotherapy treatment. Each cycle is 14 days; a total of six cycles will be administered. Patients will receive growth factor support at the discretion of treating physician.

Trial Locations (3)

77030

RECRUITING

Baylor College of Medicine, Houston

RECRUITING

Baylor St. Luke's Medical Center (BSLMC)., Houston

RECRUITING

Houston Methodist Hospital, Houston

All Listed Sponsors
collaborator

Merck Sharp & Dohme LLC

INDUSTRY

collaborator

The Methodist Hospital Research Institute

OTHER

lead

Baylor College of Medicine

OTHER