Neurostimulation to Improve NOWS Outcomes

NAActive, not recruitingINTERVENTIONAL
Enrollment

52

Participants

Timeline

Start Date

July 27, 2022

Primary Completion Date

December 25, 2024

Study Completion Date

August 31, 2025

Conditions
Neonatal Opioid Withdrawal SyndromeNeonatal Abstinence Syndrome
Interventions
DEVICE

Sparrow Fledging Therapy System

tAN sessions will be administered up to four times per day for up to 20 days total. Active tAN will be set to run for 30 minutes one hour prior to each planned morphine dose. When the 30-minute tAN session is complete, the system will be turned off and unplugged.

DEVICE

Sham Sparrow Fledging Therapy System

Participants randomized to the sham group will have the device earpiece applied at the same timepoints and for the same duration as the active group, but stimulation will not be turned on. tAN sessions will be administered up to four times per day for up to 20 days total. Sham tAN will be set to run for 30 minutes one hour prior to each planned morphine dose. When the 30-minute tAN session is complete, the system will be turned off and unplugged.

Trial Locations (3)

29425

Medical University of South Carolina - Shawn Jenkins Children's Hospital, Charleston

75235

UT Southwestern Medical Center / Parkland Memorial Hospital, Dallas

78229

University of Texas Health Science Center San Antonio, San Antonio

All Listed Sponsors
collaborator

Medical University of South Carolina

OTHER

collaborator

University of Texas Southwestern Medical Center

OTHER

collaborator

University of Texas Health Science Center San Antonio

UNKNOWN

lead

Spark Biomedical, Inc.

INDUSTRY